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Literature DB >> 4182344

Limited periods of gene expression in immunoglobulin-synthesizing cells.

Abstract

In synchronized human lymphoid cell lines, production of immunoglobulins G and M is greatest during the late Gl and S phases of the cell cycle. Little immunoglobulin appears immediately before, during, and immediately after mitosis. The results indicate that transcription of immunoglobulin genes takes place during a limited part of the mitotic cycle.

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Year: 1969 PMID： 4182344 DOI： 10.1126/science.164.3887.1524

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

36 in total

1. Ultrastructural and serological studies on the resistance of activated B cells to the cytotoxic effects of anti-immunoglobulin serum. Patch and cap formation of surface immunoglobulin on mitotic B lymphocytes.

Authors: R S Kerbel; M S Birbeck; D Robertson; P Cartwright
Journal: Clin Exp Immunol Date: 1975-04 Impact factor: 4.330

2. Induction of erythroid differentiation by dimethylsulfoxide in cells infected with Friend virus: relationship to the cell cycle.

Authors: J Levy; M Terada; R A Rifkind; P A Marks
Journal: Proc Natl Acad Sci U S A Date: 1975-01 Impact factor: 11.205

Review 8. Immunoglobulins.

Authors: J Bradley
Journal: J Med Genet Date: 1974-03 Impact factor: 6.318

9. Morphological aspects of human lymphoid cells grown in vitro.

Authors: B Drewinko; J M Trujillo
Journal: In Vitro Date: 1972 Mar-Apr

10. Automatic monitoring of biochemical parameters in tissue culture. Studies on synchronously growing mouse myeloma cells.

Authors: N J Cowan; C Milstein
Journal: Biochem J Date: 1972-06 Impact factor: 3.857

Limited periods of gene expression in immunoglobulin-synthesizing cells.

1. Ultrastructural and serological studies on the resistance of activated B cells to the cytotoxic effects of anti-immunoglobulin serum. Patch and cap formation of surface immunoglobulin on mitotic B lymphocytes.

2. Induction of erythroid differentiation by dimethylsulfoxide in cells infected with Friend virus: relationship to the cell cycle.

3. Relationship between cell size, cell cycle and specific recombinant protein productivity.

4. The role of the cell cycle in determining gene expression and productivity in CHO cells.

5. Anti-apoptotic genes, bag-1 and bcl-2, enabled hybridoma cells to survive under treatment for arresting cell cycle.

Review 6. Human lymphoid cell lines: models for immunological analysis.

7. Immunofluorescence studies on immunoglobulins in the lymphoid cells of human peripheral blood.

Review 8. Immunoglobulins.

9. Morphological aspects of human lymphoid cells grown in vitro.

10. Automatic monitoring of biochemical parameters in tissue culture. Studies on synchronously growing mouse myeloma cells.