| Literature DB >> 4180575 |
K M Foley, B S Danes, A G Bearn.
Abstract
Cultures of white cells derived from peripheral blood of individuals homozygous and heterozygous for the inherited mucopolysaccharidoses revealed a distinct intracellular metachromatic staining with toluidine blue O. These short-term cultures circumvent the technical problems of skin fibroblast cultures and provide a simple screening procedure to detect the heterozygous state for the mucopolysaccharidoses, as well as offering an opportunity to study the heterozygous state of various inherited storage diseases.Entities:
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Year: 1969 PMID： 4180575 DOI： 10.1126/science.164.3878.424
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728