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Literature DB >> 41800

Biochemical mechanism of nitrofurantoin resistance in Vibrio el tor.

P Ghosh Dastidar, A M Sinha, S Ghosh, G C Chatterjee.

Abstract

Vibrio el tor cells contain a constitutive reductase enzyme which converts nitrofurantoin to an active principle that is responsible for the observed antibacterial activity of the drug. Acquisition of resistance of this strain towards nitrofurantoin is associated with the loss of this reductase. This enzyme is located in the periplasmic region of the nitrofurantoin-sensitive cells, and seems to play an important role in transporting the drug into the cells.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1979 PMID： 41800 DOI： 10.1007/bf02927181

Source DB: PubMed Journal: Folia Microbiol (Praha) ISSN： 0015-5632 Impact factor: 2.099

14 in total

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Authors: R Benveniste; J Davies
Journal: Annu Rev Biochem Date: 1973 Impact factor: 23.643

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Journal: J Biol Chem Date: 1965-09 Impact factor: 5.157

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Authors: G Bhattacharya; P G Dastidar; P K Majumder; G C Chatterjee
Journal: Acta Microbiol Pol A Date: 1973

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Authors: K Kato; Y Sugino; H Endo
Journal: Biochim Biophys Acta Date: 1966-05-19

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Authors: P Herrlich; M Schweiger
Journal: Proc Natl Acad Sci U S A Date: 1976-10 Impact factor: 11.205

10. Mode of action of nitrofurazone.

Authors: D R McCalla; A Reuvers; C Kaiser
Journal: J Bacteriol Date: 1970-12 Impact factor: 3.490

1 in total

1. Lysis of nitrofurantoin-resistant strain of Vibrio el tor.

Authors: S Haldar; R Tiwari; A Bhattacharyya; A Basu; G C Chatterjee
Journal: Folia Microbiol (Praha) Date: 1983 Impact factor: 2.099

1 in total