Literature DB >> 417864

[Effects of chronic paralysis of chick embryo by flaxedil on the development of the neuromuscular junction].

J P Bourgeois, H Betz, J P Changuex.   

Abstract

Chronic paralysis of Chick embryos by the cholinergic antagonist flaxedil blocks the subsynaptic accumulation of acetylcholinesterase but not the formation of acetylcholine receptor cluster. Flaxedil paralysis also causes an increase of the total muscle content of acetylcholine receptor without altering the half-life of the receptor protein. The spontaneous activity of the embryon therefore "shuts off" the synthesis of extrasynpatic acetylcholine receptor.

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Year:  1978        PMID： 417864

Source DB:  PubMed          Journal:  C R Acad Hebd Seances Acad Sci D


  4 in total

Review 1.  Activity-dependent regulation of gene expression in muscle and neuronal cells.

Authors:  R Laufer; J P Changeux
Journal:  Mol Neurobiol       Date:  1989 Spring-Summer       Impact factor: 5.590

2.  Evolution of cholinergic proteins in developing slow and fast skeletal muscles in chick embryo.

Authors:  H Betz; J P Bourgeois; J P Changeux
Journal:  J Physiol       Date:  1980-05       Impact factor: 5.182

3.  Appearance and distribution "in situ" of nicotinic acetylcholine receptors in cervical myotomes of young chick embryos. Radioautographic studies by light and electron microscopy.

Authors:  R Meiniel; J P Bourgeois
Journal:  Anat Embryol (Berl)       Date:  1982

4.  Localization of nicotinic acetylcholine receptor alpha-subunit transcripts during myogenesis and motor endplate development in the chick.

Authors:  B Fontaine; J P Changeux
Journal:  J Cell Biol       Date:  1989-03       Impact factor: 10.539
  4 in total

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