| Literature DB >> 417802 |
V Ivanovic, N E Geacintov, A M Jeffrey, P P Fu, R G Harvey, I B Weinstein.
Abstract
Fluorescence spectra of DNA isolated from hamster embryo cells incubated with 7,12-dimethylbenz(a)anthracene, or DNA modified in a microsomal system by reaction with this carcinogen or its 7-hydroxymethyl derivative, were compared to various model compounds. The spectra indicate that the DMBA derivative bound to DNA, in all 3 cases, has a 9,10-dimethylanthracene-like chromophore. They also provide the first evidence of the similarity in structure of the DNA-bound products between 7,12-dimethylbenz(a)anthracene and its 7-hydroxymethyl derivative. Our results are consistent with an activation mechanism that involves saturation of the 1,2,3,4-ring positions.Entities:
Mesh：
Substances：
Year: 1978 PMID： 417802 DOI： 10.1016/s0304-3835(78)93962-9
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679