Literature DB >> 4174453

Histamine release in vitro: inhibition by catecholamines and methylxanthines.

L M Lichtenstein, S Margolis.   

Abstract

Methylxanthines and catecholamines both inhibit antigenically induced histamine release from human leukocytes. They act synergistically to inhibit the reaction, but must be present when antigen is added; preincubation is not effective. Since both increase cellular levels of cyclic 3 ', 5'-adenosine monophosphate it is postulated that this compound plays a role in the regulation of allergic histamine release.

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Year:  1968        PMID： 4174453     DOI： 10.1126/science.161.3844.902

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  100 in total

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