Measurement of rubella antibody in immunoglobulin: its disappearance from the blood after injection. Report of the Public Health Laboratory Service Working Party on Rubella.

Rubella antibody titrations were done on samples of human immunoglobulin by neutralization and haemagglutination-inhibition methods. No significant variation was found in the antibody content of different batches. The specificity of the methods was confirmed by tests on a batch of human globulin specially prepared from plasma samples lacking rubella antibody.Divided doses of immunoglobulin were given to volunteers who had no rubella antibody. Low titres were then detected in the blood for a limited period and the disappearance of this antibody was followed.