Literature DB >> 417194

Membrane-free scrapie activity.

T G Malone, R F Marsh, R P Hanson, J S Semancik.   

Abstract

Determinations of scrapie activity in subcellular fractions from infected hamster brains through the asymptomatic and symptomatic course of infection revealed the presence of substantial amounts of scrapie infectivity in the 100,000 X g supernatant fractions, indicating that association with physically discernible membrane structures is not necessary for the transmission of the scrapie agent. An increase of scrapie infectivity in the 100,000 X g supernatant fractions after vigorous homogenization of infected membrane-rich fractions suggests that the agent is identical in membrane-rich and 100,000 X g supernatant fractions.

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Year:  1978        PMID： 417194      PMCID： PMC525990     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  11 in total

1.  THE INTRACELLULAR LOCATION OF THE AGENT OF MOUSE SCRAPIE.

Authors:  G D HUNTER; G C MILLSON; G MEEK
Journal:  J Gen Microbiol       Date:  1964-02

2.  Properties of the scrapie agent-endomembrane complex from hamster brain.

Authors:  J S Semancik; R F Marsh; J L Geelen; R P Hanson
Journal:  J Virol       Date:  1976-05       Impact factor: 5.103

3.  An experimental examination of the scrapie agent in cell membrane mixtures. II. The association of scrapie activity with membrane fractions.

Authors:  G C Millson; G D Hunter; R H Kimberlin
Journal:  J Comp Pathol       Date:  1971-04       Impact factor: 1.311

Review 4.  Nature of the scrapie agent.

Authors:  R A Gibbons; G D Hunter
Journal:  Nature       Date:  1967-09-02       Impact factor: 49.962

5.  Centrifugation studies on the infectivities of cellular fractions derived from mouse brain infected with scrapie (Suffolk strain).

Authors:  D L Mould; W Smith; A M Dawson
Journal:  J Gen Microbiol       Date:  1965-07

6.  Partial purification of the scrapie agent from mouse brain by pressure disruption and zonal centrifugation in sucrose-sodium chloride gradients.

Authors:  A N Siakotos; D C Gajdusek; C J Gibbs; R D Traub; C Bucana
Journal:  Virology       Date:  1976-03       Impact factor: 3.616

7.  The membrane location of scrapie infectivity.

Authors:  M C Clarke; G C Millson
Journal:  J Gen Virol       Date:  1976-06       Impact factor: 3.891

8.  Attempts to release the scrapie agent from tissue debris.

Authors:  G D Hunter; G C Millson
Journal:  J Comp Pathol       Date:  1967-07       Impact factor: 1.311

9.  An experimental examination of the scrapie agent in cell membrane mixtures. I. Stability and physicochemical properties of the scrapie agent.

Authors:  G D Hunter; R H Kimberlin; G C Millson; R A Gibbons
Journal:  J Comp Pathol       Date:  1971-01       Impact factor: 1.311

10.  Transmissible mink encephalopathy. Reduced spongiform degeneration in aged mink of the Chediak-Higashi genotype.

Authors:  R F Marsh; J C Sipe; S S Morse; R P Hanson
Journal:  Lab Invest       Date:  1976-04       Impact factor: 5.662
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  8 in total

Review 1.  Prion propagation: the role of protein dynamics.

Authors:  John A Pezza; Tricia R Serio
Journal:  Prion       Date:  2007-01-10       Impact factor: 3.931

Review 2.  Prion liposomes.

Authors:  R Gabizon; S B Prusiner
Journal:  Biochem J       Date:  1990-02-15       Impact factor: 3.857

3.  Ultrastructural studies on scrapie prion protein crystals obtained from reverse micellar solutions.

Authors:  H Wille; S B Prusiner
Journal:  Biophys J       Date:  1999-02       Impact factor: 4.033

4.  Pathogenesis of hamster scrapie. Adherent splenocytes are associated with relatively high levels of infectivity.

Authors:  M M Robinson; J R Gorham
Journal:  Arch Virol       Date:  1990       Impact factor: 2.574

5.  Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity.

Authors:  D Riesner; K Kellings; K Post; H Wille; H Serban; D Groth; M A Baldwin; S B Prusiner
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103

6.  Attempts to restore scrapie prion infectivity after exposure to protein denaturants.

Authors:  S B Prusiner; D Groth; A Serban; N Stahl; R Gabizon
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

7.  Experimental scrapie in golden Syrian hamsters: temporal comparison of in vitro cell-fusing activity with brain infectivity and histopathological changes.

Authors:  M C Moreau-Dubois; P Brown; R G Rohwer; C L Masters; M Franko; D C Gajdusek
Journal:  Infect Immun       Date:  1982-07       Impact factor: 3.441

Review 8.  Heterogeneity and Architecture of Pathological Prion Protein Assemblies: Time to Revisit the Molecular Basis of the Prion Replication Process?

Authors:  Angélique Igel-Egalon; Jan Bohl; Mohammed Moudjou; Laetitia Herzog; Fabienne Reine; Human Rezaei; Vincent Béringue
Journal:  Viruses       Date:  2019-05-10       Impact factor: 5.048
  8 in total

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