Literature DB >> 4165502

Studies on the control of antibody synthesis. Interaction of antigenic competition and suppression of antibody formation by passive antibody on the immune response.

N I Brody, J G Walker, G W Siskind.   

Abstract

In the system studied, antigenic competition between two haptenic determinants was found to be of the same extent whether the haptens were on the same or on separate carrier molecules. Suppression of antibody formation to one determinant by administration of passive antibody partially eliminated the depressive effects of antigenic competition when the two haptens were located on separate carrier molecules but had no effect on antibody production to the second hapten when the two determinants were present on the same molecule. The results are discussed in terms of the mechanisms of suppression, antigenic competition, and control of antibody formation.

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Year:  1967        PMID: 4165502      PMCID: PMC2138300          DOI: 10.1084/jem.126.1.81

Source DB:  PubMed          Journal:  J Exp Med        ISSN: 0022-1007            Impact factor:   14.307


  13 in total

1.  QUANTITATIVE STUDIES ON THE PRECIPITATION OF ANTI-2,4DINITROPHENYL ANTIBODY IN ANTIGEN EXCESS.

Authors:  G W SISKIND
Journal:  J Immunol       Date:  1964-05       Impact factor: 5.422

2.  INHIBITION OF 19S ANTIBODY SYNTHESIS BY 7S ANTIBODY.

Authors:  K SAHIAR; R S SCHWARTZ
Journal:  Science       Date:  1964-07-24       Impact factor: 47.728

3.  Azoproteins. II. A spectrophotometric study of the coupling of diazotized arsanilic acid with proteins.

Authors:  M TABACHNICK; H SOBOTKA
Journal:  J Biol Chem       Date:  1960-04       Impact factor: 5.157

4.  Studies of hypersensitivity to low molecular weight substances. III. The 2,4-dinitrophenyl group as a determinant in the preciptin reaction.

Authors:  H N EISEN; M E CARSTEN; S BELMAN
Journal:  J Immunol       Date:  1954-11       Impact factor: 5.422

5.  Spectrometric evaluation of the approximate pK of the carboxyl group in 2,4-dinitrophenyl-amino acids.

Authors:  L K RAMACHANDRAN; L V SASTRY
Journal:  Biochemistry       Date:  1962-01       Impact factor: 3.162

6.  Antibody synthesis at the cellular level. Antibody-induced suppression of 7S antibody synthesis.

Authors:  H Wigzell
Journal:  J Exp Med       Date:  1966-11-01       Impact factor: 14.307

7.  HOMEOSTASIS OF ANTIBODY FORMATION IN THE ADULT RAT.

Authors:  D A ROWLEY; F W FITCH
Journal:  J Exp Med       Date:  1964-12-01       Impact factor: 14.307

8.  Antibody formation. I. The suppression of antibody formation by passively administered antibody.

Authors:  J W UHR; J B BAUMANN
Journal:  J Exp Med       Date:  1961-05-01       Impact factor: 14.307

9.  A study of the distribution of 2,4-dinitrobenzene sensitizers between isolated lymph node cells and extracellular medium in relation to induction of contact skin sensitivity.

Authors:  H N EISEN; M KERN; W T NEWTON; E HELMREICH
Journal:  J Exp Med       Date:  1959-08-01       Impact factor: 14.307

10.  Antibody formation in vitro.

Authors:  M FISHMAN
Journal:  J Exp Med       Date:  1961-12-01       Impact factor: 14.307

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  28 in total

Review 1.  Functions of antibodies in the regulation of B cell responses in vivo.

Authors:  B Heyman
Journal:  Springer Semin Immunopathol       Date:  2001-12

2.  Efficient IgG-mediated suppression of primary antibody responses in Fcgamma receptor-deficient mice.

Authors:  M C Karlsson; S Wernersson; T Diaz de Ståhl; S Gustavsson; B Heyman
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

Review 3.  Antibody-mediated immunomodulation: a strategy to improve host responses against microbial antigens.

Authors:  L Jeannine Brady
Journal:  Infect Immun       Date:  2005-02       Impact factor: 3.441

4.  Inhibitory effect of carrier and hapten preimmunization on delayed hypersensitivity to the carrier.

Authors:  P J Neveu
Journal:  Immunology       Date:  1976-08       Impact factor: 7.397

5.  The localization of allogeneic lymphoid cells in relation to antibody-mediated immunosuppression.

Authors:  J D Milton
Journal:  Immunology       Date:  1979-03       Impact factor: 7.397

6.  Antigenic specificities of antibodies suppressing induction of delayed hypersensitivity in mice to dinitrophenylated proteins.

Authors:  K Yonemasu; A J Crowle
Journal:  Immunology       Date:  1973-10       Impact factor: 7.397

7.  Studies on antigenic competition. II. Evidence for effect at level of antigen 'processing'.

Authors:  N I Brody; G W Siskind
Journal:  Immunology       Date:  1972-01       Impact factor: 7.397

8.  Studies on antigenic competition. II. Abolition of antigenic competition by antibody against or tolerance to the dominant antigen: a model for antigenic competition.

Authors:  M J Taussig; P J Lachmann
Journal:  Immunology       Date:  1972-02       Impact factor: 7.397

Review 9.  Suppression of the immune response.

Authors:  J Bradley; C J Elson
Journal:  J Med Genet       Date:  1971-09       Impact factor: 6.318

10.  Differences in the immune response of rabbits to p-aminobenzoic acid and sulphanilic acid, conjugated with BGG.

Authors:  B Skárová; I Ríha; V Pesák
Journal:  Folia Microbiol (Praha)       Date:  1968       Impact factor: 2.099

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