Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Studies of human anti-gamma-globulin factors reacting with pepsin-digested gamma-globulins.

Literature DB >> 4163708

Studies of human anti-gamma-globulin factors reacting with pepsin-digested gamma-globulins.

Abstract

Many sera from normal individuals as well as patients with various disease states contain agglutinating antibodies which show specificity for antigenic determinants of gamma-globulin revealed by pepsin digestion at pH 4.1. Sera containing such agglutinating activity as well as sera negative for these agglutinators contain low molecular weight (3S-5S) components of slow gamma-mobility which inhibit these agglutination reactions. Low molecular weight inhibitors show both auto- and isospecificity, and are antigenically related to the 5S pepsin fragment of gamma-globulin. A common situation is thereby revealed in which human anti-gamma-globulin antibodies showing specificity for pepsin-digested gamma-globulins are present in serum along with low molecular weight gamma-globulin components capable of inhibition. Autoreactivity or autospecificity of such anti-gamma-globulin factors is a phenomenon shared by both normal human sera and sera from patients with various disease states.

Entities: Species

Mesh：

Substances：

Year: 1967 PMID： 4163708 PMCID： PMC2138353 DOI： 10.1084/jem.125.2.233

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

16 in total

1. LOW MOLECULAR WEIGHT GAMMA-GLOBULINS OF URINE AND PLASMA AND THEIR RELATION TO 7S GAMMA-2-GLOBULIN.

Authors: P FIREMAN; E HERSHGOLD; F CORDOBA; K SCHMID; D GITLIN
Journal: Nature Date: 1964-07-04 Impact factor: 49.962

2. CHEMICAL STUDIES ON IMMUNOGLOBULINS. I. A NEW PREPARATIVE PROCEDURE FOR GAMMA-GLOBULINS EMPLOYING GLYCINE-RICH SOLVENT SYSTEMS.

Authors: J PORATH; N UI
Journal: Biochim Biophys Acta Date: 1964-08-19

10. The in vivo formation and fate of antigen-antibody complexes formed by fragments and polypeptide chains of rabbit gamma-G-antibodies.

Authors: H L Spiegelberg; W O Weigle
Journal: J Exp Med Date: 1966-06-01 Impact factor: 14.307

13 in total

1. Naturally occurring antiglobulin factors in virus neutralization: homoreactant as a factor enhancing neutralization of the infectious complex of poliovirus with the Fab' antibody fragment.

Authors: A J Kulberg; J V Pervikov
Journal: Infect Immun Date: 1976-02 Impact factor: 3.441

6. Anti-globulin antibodies detecting hidden gamma G antigens: characterization of the "pepsin site" by different immune antisera.

Authors: S D Litwin
Journal: Immunology Date: 1970-09 Impact factor: 7.397

7. IgG hydrolysis in abscesses. I. A study of the IgG in human abscess fluid.

Authors: M Waller
Journal: Immunology Date: 1974-04 Impact factor: 7.397

8. Serum agglutinators in families with twins.

Authors: M Waller; N Curry
Journal: Immunology Date: 1971-08 Impact factor: 7.397

9. Immune responses to the cleavage-associated neoantigens of fibrinogen in man. Identification and characterization of humoral antibodies specific for cleavage fragments.

Authors: E F Plow; T S Edgington
Journal: J Clin Invest Date: 1975-12 Impact factor: 14.808

10. Molecular events responsible for modulation of neoantigenic expression: the cleavage-associated neoantigen of fibrinogen (blood coagulation-fibrinogen cleavage products-fibrinolysis-molecular conformation).

Authors: E Plow; T S Edgington
Journal: Proc Natl Acad Sci U S A Date: 1972-01 Impact factor: 11.205

Studies of human anti-gamma-globulin factors reacting with pepsin-digested gamma-globulins.

1. LOW MOLECULAR WEIGHT GAMMA-GLOBULINS OF URINE AND PLASMA AND THEIR RELATION TO 7S GAMMA-2-GLOBULIN.

2. CHEMICAL STUDIES ON IMMUNOGLOBULINS. I. A NEW PREPARATIVE PROCEDURE FOR GAMMA-GLOBULINS EMPLOYING GLYCINE-RICH SOLVENT SYSTEMS.

3. High specific activity iodination of gamma-globulin with iodine-131 monochloride.

4. A serum with an albumin-active, auto-agglutinating property.

5. Zone electrophoresis.

6. Heterogeneity of anti-gamma-globulin factors detected by pepsin-digested human gamma G-globulin.

7. Light-chain disease. An abortive variant of multiple myeloma.

8. Reaction of human anti-antibodies with incomplete anti-D and its sub-units.

9. Variations among gamma-globulins at the antigenic site revealed by pepsin digestion.

10. The in vivo formation and fate of antigen-antibody complexes formed by fragments and polypeptide chains of rabbit gamma-G-antibodies.

1. Naturally occurring antiglobulin factors in virus neutralization: homoreactant as a factor enhancing neutralization of the infectious complex of poliovirus with the Fab' antibody fragment.

2. Evidence for immune complexes containing antibody to the pepsin site of IgG in rheumatoid synovial fluids.

3. The relationship between rheumatoid factors and serum agglutinators.

4. Naturally occurring pepsin agglutinators in the serum of subhuman primates.

5. Human anti-gamma-globulin antibodies specific for gamma G heavy chain subclasses.

6. Anti-globulin antibodies detecting hidden gamma G antigens: characterization of the "pepsin site" by different immune antisera.

7. IgG hydrolysis in abscesses. I. A study of the IgG in human abscess fluid.

8. Serum agglutinators in families with twins.

9. Immune responses to the cleavage-associated neoantigens of fibrinogen in man. Identification and characterization of humoral antibodies specific for cleavage fragments.

10. Molecular events responsible for modulation of neoantigenic expression: the cleavage-associated neoantigen of fibrinogen (blood coagulation-fibrinogen cleavage products-fibrinolysis-molecular conformation).