Mouse immunoglobulin allotypes: detection with rabbit antiserums.

An antiserum with allotypic specificity for mouse gamma(2a)-globulins was prepared in a rabbit by injection of 7S gamma(2)-globulin of C(57)BL/6 mice. The antibody reacted with an isoantigen in the 7S gamma(2)-globulins of normal serum of mouse strains belonging to the lg-1(b) allotype class (C(57)BL/6, C(57)BL/10, and SJL strains). No precipitin reaction was observed with serum from 18 other inbred mice strains representing other lg-1 allotype classes.