Literature DB >> 4162155

Multiple sclerosis: correlation between immunoglobulin-G in cerebrospinal fluid and brain.

W W Tourtellotte, J A Parker.   

Abstract

There is a positive correlation between the concentration of immunoglobulin-G in plaques of demyelination due to multiple sclerosis (as well as in white matter of normal appearance) and the concentration of this globulin in the cerebrospinal fluid. The tentative conclusion drawn from these results was that, in patients with multiple sclerosis, the increase in immuno-globulin-G in the cerebrospinal fluid is a reflection of an excess of this globulin in the brain.

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Year:  1966        PMID： 4162155     DOI： 10.1126/science.154.3752.1044

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

Review 1.  B cells in multiple sclerosis: connecting the dots.

Authors:  H-Christian von Büdingen; Amit Bar-Or; Scott S Zamvil
Journal:  Curr Opin Immunol       Date:  2011-10-07       Impact factor: 7.486

2.  Dual implication of 2',3'-cyclic nucleotide 3' phosphodiesterase as major autoantigen and C3 complement-binding protein in the pathogenesis of multiple sclerosis.

Authors:  M J Walsh; J M Murray
Journal:  J Clin Invest       Date:  1998-05-01       Impact factor: 14.808

3.  Autosensitization and multiple sclerosis.

Authors: 
Journal:  Can Med Assoc J       Date:  1967-03-11       Impact factor: 8.262

4.  Measles and multiple sclerosis.

Authors:  E Norrby; B Vandvik
Journal:  Proc R Soc Med       Date:  1974-11

5.  Immunoglobulin levels in the cerebrospinal fluid.

Authors:  D Riddoch; R A Thompson
Journal:  Br Med J       Date:  1970-02-14

6.  Immunoglobulin G in multiple sclerosis brain.

Authors:  T Hosokawa; J C Hunt; J J Marchalonis; E L Hogan
Journal:  Metab Brain Dis       Date:  1988-09       Impact factor: 3.584

Review 7.  [Multiple sclerosis. Principles and hypotheses of research on its cause].

Authors:  H J Bauer
Journal:  Z Neurol       Date:  1970

8.  Immunological dysfunctions in multiple sclerosis. I. Diminution of 'active' thymus-derived lymphocytes and presence of immunomodulating serum factors.

Authors:  J R Kateley; S J Bazzell
Journal:  Clin Exp Immunol       Date:  1979-02       Impact factor: 4.330

9.  Cerebrospinal fluid in multiple sclerosis: relationships between immunoglobulins, leucocytes and clinical features.

Authors:  R W Walker; E J Thompson; W I McDonald
Journal:  J Neurol       Date:  1985       Impact factor: 4.849

10.  Immune complexes in multiple sclerosis: relation to clinical pattern.

Authors:  U Patzold; P Haller; B Baruth; W Liman; H Deicher
Journal:  J Neurol       Date:  1980       Impact factor: 4.849
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