Literature DB >> 4160998

Biosynthesis of gamma globulin: studies in a cell-free system.

K H Stenzel, A L Rubin.   

Abstract

Incorporation of C(14)-amino acids into high-molecular-weight material precipitable by trichloroacetic acid indicates that microsomal cell-free systems, derived from spleens of immunized rabbits, are active in protein synthesis. Protein was made soluble by ultrasonic irradiation of the cell-free incubation mixtures, and low-molecular-weight materials were removed by dialysis and gel filtration. Chromatography and radio-immunoelectrophoresis of this soluble protein fraction reveal C(14)-labeled protein having several characteristics of gamma globulin.

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Year:  1966        PMID： 4160998     DOI： 10.1126/science.153.3735.537

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  3 in total

1.  Synthesis of gamma G antibody and immunoglobulin on polyribosomes in a cell-free system.

Authors:  J P Gusdon; A B Stavitsky; S A Armentrout
Journal:  Proc Natl Acad Sci U S A       Date:  1967-09       Impact factor: 11.205

2.  Chemical identification of specific immunoglobulins as the product of a cell-free system from plasmocytoma tumors.

Authors:  B Mach; H Koblet; D Gros
Journal:  Proc Natl Acad Sci U S A       Date:  1968-02       Impact factor: 11.205

3.  Studies on cell-free synthesis of rat immunoglobulins, I. A cell-free system for protein synthesis prepared from lymph-node microsomal vesicles.

Authors:  P Vassalli
Journal:  Proc Natl Acad Sci U S A       Date:  1967-11       Impact factor: 11.205
  3 in total

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