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Literature DB >> 4159288

Degradation of ribonucleic acid in mouse fibroblasts treated with actinomycin.

Abstract

The cellular RNA content of mouse fibroblasts incubated with actinomycin decreases at a rate of about 1 to 1.5 per cent per hour, while DNA and protein content remain unchanged. This degradation affects nuclear and cytoplasmic RNA, ribosomal and soluble RNA. The breakdown products appear quantitatively in the acid-soluble fraction of the cells and the medium. Polynucleotides synthesized a short period (120 minutes) prior to exposure to actinomycin are degraded before those synthesized 8 to 12 hours previously.

Entities: CellLine Chemical Disease Species

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Year: 1965 PMID： 4159288 PMCID： PMC2106805 DOI： 10.1083/jcb.27.1.47

Source DB: PubMed Journal: J Cell Biol ISSN： 0021-9525 Impact factor: 10.539

11 in total

1. BREAKDOWN OF NUCLEAR RIBONUCLEIC ACID IN THE PRESENCE OF ACTINOMYCIN D.

Authors: H HARRIS
Journal: Nature Date: 1964-06-27 Impact factor: 49.962

2. EFFECT OF ACTINOMYCIN D ON HELA CELL NUCLEAR RNA METABOLISM.

Authors: H B LEVY
Journal: Proc Soc Exp Biol Med Date: 1963 Aug-Sep

3. Effect of mitomycin C on mammalian cells in culture.

Authors: A J SHATKIN; E REICH; R M FRANKLIN; E L TATUM
Journal: Biochim Biophys Acta Date: 1962-03-05

4. Rapidly labelled ribonucleic acid in the cell nucleus.

Authors: H HARRIS
Journal: Nature Date: 1963-04-13 Impact factor: 49.962

5. Changes in the metabolism of ribonucleic acid preceding the synthesis of deoxyribonucleic acid in mammalian cells cultured from the animal.

Authors: I LIEBERMAN; R ABRAMS; P OVE
Journal: J Biol Chem Date: 1963-06 Impact factor: 5.157

6. In vitro studies with HeLa cell line sensitive and resistant to actinomycin D.

Authors: M N GOLDSTEIN; I J SLOTNICK; L J JOURNEY
Journal: Ann N Y Acad Sci Date: 1960-10-05 Impact factor: 5.691

7. Nutrition needs of mammalian cells in tissue culture.

Authors: H EAGLE
Journal: Science Date: 1955-09-16 Impact factor: 47.728

8. Action of actinomycin D on animal cells and viruses.

Authors: E REICH; R M FRANKLIN; A J SHATKIN
Journal: Proc Natl Acad Sci U S A Date: 1962-07-15 Impact factor: 11.205

9. Sedimentation characteristics of rapidly labelled RNA from HeLa cells.

Authors: K SCHERRER; J E DARNELL
Journal: Biochem Biophys Res Commun Date: 1962-06-04 Impact factor: 3.575

10. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

12 in total

1. Actinomycin D and the hormonal induction of amylase synthesis in barley aleurone layers.

Authors: P B Goodwin; D J Carr
Journal: Planta Date: 1972-03 Impact factor: 4.116

2. Induction of tyrosine alpha-ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line.

Authors: E B Thompson; G M Tomkins; J F Curran
Journal: Proc Natl Acad Sci U S A Date: 1966-07 Impact factor: 11.205

Degradation of ribonucleic acid in mouse fibroblasts treated with actinomycin.

1. BREAKDOWN OF NUCLEAR RIBONUCLEIC ACID IN THE PRESENCE OF ACTINOMYCIN D.

2. EFFECT OF ACTINOMYCIN D ON HELA CELL NUCLEAR RNA METABOLISM.

3. Effect of mitomycin C on mammalian cells in culture.

4. Rapidly labelled ribonucleic acid in the cell nucleus.

5. Changes in the metabolism of ribonucleic acid preceding the synthesis of deoxyribonucleic acid in mammalian cells cultured from the animal.

6. In vitro studies with HeLa cell line sensitive and resistant to actinomycin D.

7. Nutrition needs of mammalian cells in tissue culture.

8. Action of actinomycin D on animal cells and viruses.

9. Sedimentation characteristics of rapidly labelled RNA from HeLa cells.

10. Protein measurement with the Folin phenol reagent.

1. Actinomycin D and the hormonal induction of amylase synthesis in barley aleurone layers.

2. Induction of tyrosine alpha-ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line.

3. Cytology of cultured cells surviving actinomycin D.

4. Serum-induced formation of lysosomes in HeLa cells: a process sensitive to actinomycin D.

5. Actinomycin D-induced phenocopies in Drosophila melanogaster and their relevance to the time of gene action.

6. Histological studies on the effect of actinomycin D on retrograde nerve cell reaction in the facial nucleus of mice.

7. The effect of proflavine on HeLa cells.

8. The effect of ribonuclease on polysomes and ribosomes of bacteria and animal cells.

9. The loss of rapidly labelled ribonucleic acid from isolated HeLa cell nuclei.

10. Kinetics of RNA synthesis in toad bladder epithelium: action of aldosterone during the latent period.