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Literature DB >> 4158352

The metabolism of gamma-2,3,4,5,6-pentachlorocyclohex-1-ene and gamma-hexachlorocyclohexane in rats.

Abstract

1. After intraperitoneal administration, gamma-hexachlorocyclohexane (Gammexane) and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene were converted by rats into 2,3,5- and 2,4,5-trichlorophenol, which were excreted as free phenols and as sulphuric acid and glucuronic acid conjugates. 2. Derivatives of 2,4,5-trichlorophenol and 2,4,5-trichlorophenyl glucosiduronic acid and 2,4-dichlorophenylmercapturic acid were isolated from the urine as metabolites of gamma-2,3,4,5,6-pentachlorocyclohex-1-ene. 3. The phenolic metabolites of gamma-hexachlorocyclohexane and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene isolated from urine were similar to those of 1,2,4-trichlorobenzene, which indicates that the two latter compounds are intermediates in gamma-hexachlorocyclohexane metabolism in rats.

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Year: 1965 PMID： 4158352 PMCID： PMC1207069 DOI： 10.1042/bj0960521

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

7 in total

1. Metabolism of benzene hexachloride by resistant houseflies Musca domestica.

Authors: F R BRADBURY; H STANDEN
Journal: Nature Date: 1959-04-04 Impact factor: 49.962

2. Studies in detoxication. 63. The metabolism of halogenobenzenes; (a) meta-dichlorobenzene (b) further observations on the metabolism of chlorobenzene.

Authors: D V PARKE; R T WILLIAMS
Journal: Biochem J Date: 1955-03 Impact factor: 3.857

3. Biochemical studies of toxic agents. 11. The occurrence of premercapturic acids.

Authors: R H KNIGHT; L YOUNG
Journal: Biochem J Date: 1958-09 Impact factor: 3.857

4. Studies in detoxication. 66. The metabolism of halogenobenzenes: 1:2:3-, 1:2:4- and 1:3:5-trichlorobenzenes.

Authors: W R JONDORF; D V PARKE; R T WILLIAMS
Journal: Biochem J Date: 1955-11 Impact factor: 3.857

5. Studies in detoxication. 37. Metabolism of benzene: examination of the glucuronide fraction of rabbit urine after administration of benzene; isolation of phenylglucuronide.

Authors: D V PARKE; R T WILLIAMS
Journal: Biochem J Date: 1951-05 Impact factor: 3.857

6. Tissue distribution, accumulation and elimination of the isomers of benzene hexachloride.

Authors: B DAVIDOW; J P FRAWLEY
Journal: Proc Soc Exp Biol Med Date: 1951-04

7. CONJUGATIONS WITH GLUTATHIONE. THE ENZYMIC CONJUGATION OF SOME CHLOROCYCLOHEXENES.

Authors: P SIMS; P L GROVER
Journal: Biochem J Date: 1965-04 Impact factor: 3.857

7 in total

10 in total

1. DNA binding and mutagenicity of lindane and its metabolites.

Authors: U V Gopalaswamy; C K Nair
Journal: Bull Environ Contam Toxicol Date: 1992-08 Impact factor: 2.151

2. The identification of five unreported lindane metabolites recovered from rat urine.

Authors: R W Chadwick; J J Freal
Journal: Bull Environ Contam Toxicol Date: 1972 Feb-Mar Impact factor: 2.151

3. Biodegradation of alpha-hexachlorocyclohexane. I. Glutathione-dependent conversion to a hydrophilic metabolite by rat liver cytosol.

Authors: J Portig; P Kraus; S Sodomann; G Noack
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

The metabolism of gamma-2,3,4,5,6-pentachlorocyclohex-1-ene and gamma-hexachlorocyclohexane in rats.

1. Metabolism of benzene hexachloride by resistant houseflies Musca domestica.

2. Studies in detoxication. 63. The metabolism of halogenobenzenes; (a) meta-dichlorobenzene (b) further observations on the metabolism of chlorobenzene.

3. Biochemical studies of toxic agents. 11. The occurrence of premercapturic acids.

4. Studies in detoxication. 66. The metabolism of halogenobenzenes: 1:2:3-, 1:2:4- and 1:3:5-trichlorobenzenes.

5. Studies in detoxication. 37. Metabolism of benzene: examination of the glucuronide fraction of rabbit urine after administration of benzene; isolation of phenylglucuronide.

6. Tissue distribution, accumulation and elimination of the isomers of benzene hexachloride.

7. CONJUGATIONS WITH GLUTATHIONE. THE ENZYMIC CONJUGATION OF SOME CHLOROCYCLOHEXENES.

1. DNA binding and mutagenicity of lindane and its metabolites.

2. The identification of five unreported lindane metabolites recovered from rat urine.

3. Biodegradation of alpha-hexachlorocyclohexane. I. Glutathione-dependent conversion to a hydrophilic metabolite by rat liver cytosol.

4. Lindane toxicity to four-month-old calves.

5. Biotransformation of lindane in the rat.

6. Porphyrin accumulation in sheep bones associated with 1, 2, 4-trichlorobenzene.

7. Biodegradation of alpha-hexachlorocyclohexane. V. Characterization of the major urinary metabolites.

8. Occupational exposure to hexachlorocyclohexane. VI. Metabolism of gamma-hexachlorocyclohexane in man.

9. Species differences in the inhibition of glutathione S-aryltransferase by phthaleins and dicarboxylic acids.

10. Model ecosystem studies of the environmental fate of six organochlorine pesticides.