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Literature DB >> 4157336

Binding of aminoglycosides to feces.

Abstract

Gentamicin and several other basic antibiotics were examined for their ability to adsorb to dog feces. It was found that 44 to 90% of all antibiotics studied were adsorbed to feces depending on the ratio of antibiotic to fecal material. Attempts to extract these antibiotics by acid treatment after adsorption onto feces were only partially successful since large portions of the bound materials were not removed.

Entities: Chemical Species

Mesh：

Substances：

Year: 1974 PMID： 4157336 PMCID： PMC444662 DOI： 10.1128/AAC.6.4.415

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

5 in total

1. REGENERATION OF ANTIBIOTIC ACTIVITY BY DEACETYLATION OF N-ACETYL DERIVATIVES OF DEOXYSTREPTAMINE-CONTAINING ANTIBIOTICS.

Authors: G H WAGMAN; M J WEINSTEIN
Journal: J Med Chem Date: 1964-11 Impact factor: 7.446

2. A critical analysis of neomycin as an intestinal antiseptic.

Authors: E J POTH; R G MARTIN; S M FROMM; R I WISE; C M HSIANG
Journal: Tex Rep Biol Med Date: 1951

3. Neomycin, a new intestinal antiseptic.

Authors: E J POTH; S M FROMM; R I WISE; C M HSIANG
Journal: Tex Rep Biol Med Date: 1950

4. Binding of antibiotics to tissue homogenates.

Authors: C M Kunin
Journal: J Infect Dis Date: 1970-01 Impact factor: 5.226

5. Pharmacokinetics of cephanone in healthy adult volunteers.

Authors: C Regamey; W M Kirby
Journal: Antimicrob Agents Chemother Date: 1973-12 Impact factor: 5.191

5 in total

7 in total

Binding of aminoglycosides to feces.

1. REGENERATION OF ANTIBIOTIC ACTIVITY BY DEACETYLATION OF N-ACETYL DERIVATIVES OF DEOXYSTREPTAMINE-CONTAINING ANTIBIOTICS.

2. A critical analysis of neomycin as an intestinal antiseptic.

3. Neomycin, a new intestinal antiseptic.

4. Binding of antibiotics to tissue homogenates.

5. Pharmacokinetics of cephanone in healthy adult volunteers.

1. Binding of aminoglycoside antibiotics to filtration materials.

2. Inhibition of antibiotic activity in vitro by synthetic melanin.

Review 3. Alternative strategies for proof-of-principle studies of antibacterial agents.

4. Effect of filtration on antimicrobial solutions.

5. Binding to and antibacterial effect of aztreonam, temocillin, gentamicin and tobramycin on human faeces.

6. Binding to and antibacterial effect of ampicillin, neomycin and polymyxin B on human faeces.

7. Selective decontamination and the anaerobic faecal flora.