Literature DB >> 4151416

Phenytoin intoxication induced by sulthiame in epileptic patients.

G W Houghton, A Richens.   

Abstract

Routine estimation of serum phenytoin levels in patients newly admitted to a Special Centre for Epilepsy showed that 40% of those receiving sulthiame in addition to phenytoin had levels in the toxic range. Four long-stay patients became drug intoxicated when sulthiame treatment was started. Sulthiame appears to inhibit the hepatic hydroxylation of phenytoin.

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Year:  1974        PMID： 4151416      PMCID： PMC494641          DOI： 10.1136/jnnp.37.3.275

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  6 in total

1.  THE USE OF OSPOLOT IN THE TREATMENT OF EPILEPSY.

Authors:  N GORDON
Journal:  Epilepsia       Date:  1964-03       Impact factor: 5.864

2.  Clinical and electroencephalographic correlations with serum levels of diphenylhydanotin.

Authors:  F BUCHTHAL; O SVENSMARK; P J SCHILLER
Journal:  Arch Neurol       Date:  1960-06

3.  Difference in the central actions of phenytoin and phenobarbitone in man, measured by critical flicker fusion threshold.

Authors:  G W Houghton; A N Latham; A Richens
Journal:  Eur J Clin Pharmacol       Date:  1973-06       Impact factor: 2.953

4.  Drug--interaction between sulthiame (Ospolot (R)) and phenytoin in the treatment of epilepsy.

Authors:  O V Olesen; O N Jensen
Journal:  Dan Med Bull       Date:  1969-05

5.  Sulthiame (Ospolot) as inhibitor of diphenylhydatoin metabolism.

Authors:  J M Hansen; M Kristensen; L Skovsted
Journal:  Epilepsia       Date:  1968-03       Impact factor: 5.864

6.  Depression of prahydroxylation of diphenylhydantoin by antituberculosis chemotherapy.

Authors:  H Kutt; W Winters; F H McDowell
Journal:  Neurology       Date:  1966-06       Impact factor: 9.910
  6 in total
  12 in total

Review 1.  Pharmacokinetic drug interactions with phenytoin (Part II).

Authors:  R L Nation; A M Evans; R W Milne
Journal:  Clin Pharmacokinet       Date:  1990-02       Impact factor: 6.447

2.  Interaction between phenytoin and imipramine.

Authors:  E Perucca; A Richens
Journal:  Br J Clin Pharmacol       Date:  1977-08       Impact factor: 4.335

Review 3.  Drug interactions that matter. A critical reappraisal.

Authors:  G T McInnes; M J Brodie
Journal:  Drugs       Date:  1988-07       Impact factor: 9.546

4.  The comparative efficacy of antiepileptic drugs for partial and tonic-clonic seizures.

Authors:  D Chadwick; D M Turnbull
Journal:  J Neurol Neurosurg Psychiatry       Date:  1985-11       Impact factor: 10.154

5.  Drug interactions and lethal drug combinations.

Authors:  A Richens
Journal:  J Clin Pathol Suppl (R Coll Pathol)       Date:  1975

6.  Neurological complications during medication of epilepsy patients.

Authors:  A I Boldyrev; E P Fleis
Journal:  Neurosci Behav Physiol       Date:  1982 Mar-Apr

7.  Effect of age, height, weight and sex on serum phenytoin concentration in epileptic patients.

Authors:  G W Houghton; A Richens; M Leighton
Journal:  Br J Clin Pharmacol       Date:  1975-06       Impact factor: 4.335

8.  Involuntary movements caused by phenytoin intoxication in epileptic patients.

Authors:  S Ahmad; J Laidlaw; G W Houghton; A Richens
Journal:  J Neurol Neurosurg Psychiatry       Date:  1975-03       Impact factor: 10.154

Review 9.  Pharmacokinetic interactions with antiepileptic drugs.

Authors:  E Perucca
Journal:  Clin Pharmacokinet       Date:  1982 Jan-Feb       Impact factor: 6.447

10.  Methods of assessment of antiepileptic drugs.

Authors:  N Milligan; A Richens
Journal:  Br J Clin Pharmacol       Date:  1981-05       Impact factor: 4.335
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