Literature DB >> 4150025

Gamma-glutamyl transpeptidase in brain capillaries: possible site of a blood-brain barrier for amino acids.

M Orlowski, G Sessa, J P Green.   

Abstract

A fraction containing capillaries and rich in gamma-glutamyl transpeptidase was isolated from homogenates of bovine brain cortex by density gradient centrifugation. The enzyme was localized in the endothelial cells by a histochemical procedure. gamma-Glutantyl transpeptidase may function in the transfer of some amino acids across the blood-brain barrier.

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Year:  1974        PMID： 4150025     DOI： 10.1126/science.184.4132.66

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  56 in total

1.  Cerebrovascular ultrastructural alterations after intra-arterial infusions of ouabain, scilla-glycosides, heparin and histamine.

Authors:  J R Wolff; C Schieweck; H Emmenegger; W Meier-Ruge
Journal:  Acta Neuropathol       Date:  1975       Impact factor: 17.088

2.  Brain gamma-glutamyltranspeptidase: characteristics, development and thyroid hormone dependency of the enzyme in isolated microvessels and neuronal/glial cell plasma membranes.

Authors:  S J Hemmings; K B Storey
Journal:  Mol Cell Biochem       Date:  1999-12       Impact factor: 3.396

Review 3.  Development of neuropeptide drugs that cross the blood-brain barrier.

Authors:  Richard D Egleton; Thomas P Davis
Journal:  NeuroRx       Date:  2005-01

4.  Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases.

Authors:  Alla L Zozulya; Emily Reinke; Dana C Baiu; Jozsef Karman; Matyas Sandor; Zsuzsanna Fabry
Journal:  J Immunol       Date:  2007-01-01       Impact factor: 5.422

5.  Cerebral microvessels and derived cells in tissue culture: isolation and preliminary characterization.

Authors:  L E DeBault; L E Kahn; S P Frommes; P A Cancilla
Journal:  In Vitro       Date:  1979-07

Review 6.  Regulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system.

Authors:  David Pimentel; Dagmar Johanna Haeussler; Reiko Matsui; Joseph Robert Burgoyne; Richard Alan Cohen; Markus Michael Bachschmid
Journal:  Antioxid Redox Signal       Date:  2012-03-15       Impact factor: 8.401

7.  Gamma-glutamyl transpeptidase does not act as a cystine transporter in brain microvessels.

Authors:  J E Wolff; G Münstermann; K Grebenkämper; M Erben
Journal:  Neurochem Res       Date:  1998-09       Impact factor: 3.996

8.  A fluorometric assay for gamma-glutamyl transpeptidase: demonstration enzymatic activity in cultured cells of neural origin.

Authors:  H D Shine; L Hertz; J De Vellis; B Haber
Journal:  Neurochem Res       Date:  1981-04       Impact factor: 3.996

9.  A new model for multiple sclerosis: chronic experimental allergic encephalomyelitis induced by immunization with cerebral endothelial cell membrane.

Authors:  N Tsukada; C S Koh; N Yanagisawa; A Okano; W M Behan; P O Behan
Journal:  Acta Neuropathol       Date:  1987       Impact factor: 17.088

10.  Cycloleucine uptake in the brainstem of thiamine-deficient rats.

Authors:  H J Manz; D M Robertson; R A Haas; N Meyers
Journal:  Acta Neuropathol       Date:  1976-09-15       Impact factor: 17.088
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