Literature DB >> 414993

Antibody mediated mechanisms of immunity to malaria induced by vaccination with Plasmodium knowlesi merozoites.

G A Butcher, G H Mitchell, S Cohen.   

Abstract

Rhesus monkeys vaccinated with merozoites in FCA are protected against challenge with several strains and variants of Plasmodium knowlesi. Vaccination induces sterilizing immunity which is species specific. Merozoite-blocking (inhibitory) antibody usually correlates with clinical immunity and protection can be passively transferred with immune sera provided these contain high levels of inhibitory antibody. However, vaccination using adjuvants other than FCA may induce inhibitory antibody without clinical protection. In addition, vaccinated animals may become susceptible to challenge 4-5 weeks after splenectomy, although inhibitory antibody levels are not reduced. These observations indicate that immunity induced by merozoite vaccination involves: (i) merozoite blocking (inhibitory) antibody, (ii) specific antibody or immune complexes acting synergistically with cytotoxic splenic cells stimulated by FCA.

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Year:  1978        PMID： 414993      PMCID： PMC1457343     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  23 in total

Review 1.  Immunology of malarial infection and its possible consequences.

Authors:  I A McGregor
Journal:  Br Med Bull       Date:  1972-01       Impact factor: 4.291

2.  Mechanisms of malarial immunity.

Authors:  S Cohen
Journal:  Trans R Soc Trop Med Hyg       Date:  1977       Impact factor: 2.184

3.  Antigenic variation and immunity to Plasmodium knowlesi: antibodies which induce antigenic variation and antibodies which destroy parasites.

Authors:  K N Brown; L A Hills
Journal:  Trans R Soc Trop Med Hyg       Date:  1974       Impact factor: 2.184

Review 4.  Immunological aspects of malaria infection.

Authors:  I N Brown
Journal:  Adv Immunol       Date:  1969       Impact factor: 3.543

5.  Method to test inhibitory antibodies in human sera to wild populations of Plasmodium falciparum.

Authors:  R J Wilson; R S Phillips
Journal:  Nature       Date:  1976-09-09       Impact factor: 49.962

6.  A freeze-dried merozoite vaccine effective against Plasmodium knowlesi malaria.

Authors:  G H Mitchell; G A Butcher; J Langhorne; S Cohen
Journal:  Clin Exp Immunol       Date:  1977-05       Impact factor: 4.330

7.  Antigenic variation and protective immunity in Plasmodium knowlesi malaria.

Authors:  G A Butcher; S Cohen
Journal:  Immunology       Date:  1972-10       Impact factor: 7.397

8.  Action of malarial antibody in vitro.

Authors:  S Cohen; G A Butcher; R B Crandall
Journal:  Nature       Date:  1969-07-26       Impact factor: 49.962

9.  Immunity to Plasmodium berghei in rats: passive serum transfer and role of the spleen.

Authors:  I N Brown; R S Phillips
Journal:  Infect Immun       Date:  1974-12       Impact factor: 3.441

10.  Immunity to Plasmodium Berghei yoelii in mice. I. The course of infection in T cell and B cell deficient mice.

Authors:  F I Weinbaum; C B Evans; R E Tigelaar
Journal:  J Immunol       Date:  1976-11       Impact factor: 5.422
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  14 in total

1.  Localization and chemical characterization of Plasmodium knowlesi schizont antigens.

Authors:  J A Deans; S Cohen
Journal:  Bull World Health Organ       Date:  1979       Impact factor: 9.408

2.  Rat monoclonal antibodies which inhibit the in vitro multiplication of Plasmodium knowlesi.

Authors:  J A Deans; T Alderson; A W Thomas; G H Mitchell; E S Lennox; S Cohen
Journal:  Clin Exp Immunol       Date:  1982-08       Impact factor: 4.330

3.  Immunization of rhesus monkeys with blood-stage antigens of Plasmodium knowlesi.

Authors:  K H Rieckmann; E J Cabrera; G H Campbell; R C Jost; R Miranda; T R O'Leary
Journal:  Bull World Health Organ       Date:  1979       Impact factor: 9.408

Review 4.  Malaria: immunity and prospects for vaccination.

Authors:  M Hommel
Journal:  West J Med       Date:  1981-10

5.  Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.

Authors:  D Lys Guilbride; Pawel Gawlinski; Patrick D L Guilbride
Journal:  PLoS One       Date:  2010-05-19       Impact factor: 3.240

6.  Plasmodium knowlesi variant antigens are found on schizont-infected erythrocytes but not on merozoites.

Authors:  M Hommel; P H David
Journal:  Infect Immun       Date:  1981-07       Impact factor: 3.441

7.  Plasmodium falciparum: protein antigens identified by analysis of serum samples from vaccinated Aotus monkeys.

Authors:  S C Kan; K M Yamaga; K J Kramer; S E Case; W A Siddiqui
Journal:  Infect Immun       Date:  1984-01       Impact factor: 3.441

Review 8.  Acquired immunity to malaria.

Authors:  Denise L Doolan; Carlota Dobaño; J Kevin Baird
Journal:  Clin Microbiol Rev       Date:  2009-01       Impact factor: 26.132

9.  Role of spleen in morbidity and mortality of Plasmodium berghei infection in mice.

Authors:  W M Eling
Journal:  Infect Immun       Date:  1980-12       Impact factor: 3.441

10.  Rhesus monkeys protected against Plasmodium knowlesi malaria produce antibodies against a 65,000-MrP. knowlesi glycoprotein at the surface of infected erythrocytes.

Authors:  R Schmidt-Ullrich; L H Miller; D F Wallach; J Lightholder; K G Powers; R W Gwadz
Journal:  Infect Immun       Date:  1981-11       Impact factor: 3.441
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