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Literature DB >> 4148919

Catecholamine concentrations and the activity of tyrosine hydroxylase after an increase in the concentration of tyrosine in rat tissues.

Abstract

The concentrations of tyrosine in rat plasma and brain were increased 2-7 fold by the administration of either L-tyrosine or cycloheximide. Under these conditions catecholamine concentrations in the brain and the heart remained unchanged even when the rats were maintained in a cold environment to increase catecholamine turnover. The data are interpreted to mean that an increase in the tyrosine concentration in the tissues does not result in an in vivo substrate inhibition of tyrosine hydroxylase.

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Year: 1972 PMID： 4148919 PMCID： PMC1666031 DOI： 10.1111/j.1476-5381.1972.tb07268.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

21 in total

1. The differential determination of catecholamines in urine.

Authors: B D DRUJAN; T L SOURKES; D S LAYNE; G F MURPHY
Journal: Can J Biochem Physiol Date: 1959-10

2. The regulation of norepinephrine synthesis in sympathetic nerves: effect of nerve stimulation, cocaine, and catecholamine-releasing agents.

Authors: A Alousi; N Weiner
Journal: Proc Natl Acad Sci U S A Date: 1966-11 Impact factor: 11.205

3. Trans-synaptic induction of adrenal tyrosine hydroxylase.

Authors: H Thoenen; R A Mueller; J Axelrod
Journal: J Pharmacol Exp Ther Date: 1969-10 Impact factor: 4.030

4. Factors influencing the rate of norepinephrine biosynthesis in nerve tissue.

Authors: R H Roth; L Stjärne; U S von Euler
Journal: J Pharmacol Exp Ther Date: 1967-12 Impact factor: 4.030

5. Mechanism of secretion from the adrenal medulla. IV. The fate of the storage vesicles following insulin and reserpine administration.

Authors: O H Viveros; L Arqueros; R J Connett; N Kirshner
Journal: Mol Pharmacol Date: 1969-01 Impact factor: 4.436

Catecholamine concentrations and the activity of tyrosine hydroxylase after an increase in the concentration of tyrosine in rat tissues.

1. The differential determination of catecholamines in urine.

2. The regulation of norepinephrine synthesis in sympathetic nerves: effect of nerve stimulation, cocaine, and catecholamine-releasing agents.

3. Trans-synaptic induction of adrenal tyrosine hydroxylase.

4. Factors influencing the rate of norepinephrine biosynthesis in nerve tissue.

5. Mechanism of secretion from the adrenal medulla. IV. The fate of the storage vesicles following insulin and reserpine administration.

6. Increased synthesis of catecholamines in the intact rat following administration of alpha-adrenergic blocking agents.

7. Increase in tyrosine hydroxylase activity after reserpine administration.

8. Acceleration of noradrenaline turnover in the mouse heart by cold exposure.

9. Acceleration of norepinephrine synthesis in the rat submaxillary gland in vivo during sympathetic nerve stimulation.

10. End-product inhibition of tyrosine hydroxylase as a possible mechanism for regulation of norepinephrine synthesis.

1. d-Tyrosine prevents hypertension in DOCA-saline treated uninephrectomised rats.

2. Dopamine synthesis by non-dopaminergic neurons in the arcuate nucleus of rat fetuses.

3. Cycloheximide and acetoxycycloheximide: inhibition of tyrosine hydroxylase activity and amnestic effects.

4. Studies on memory: inhibitors of protein synthesis also inhibit catecholamine synthesis.