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Literature DB >> 414866

An immunoglobulin heavy chain variable region (VH) marker associated with cross-reactive idiotypes in man.

Abstract

The VH specificities of two rabbit antisera raised against the H chains of two human IgM cold agglutinins were studied with the aid of proteins on which the VH sequence data are available. They were found to recognize a new VH antigen (VHMar), which may represent a subgroup of VHI. This antigen is found on anti-Ii antibodies which have cross-reactive idiotypes. It is moderately well-expressed in normal gamma globulin and strongly expressed on 8% of unselected myeloma and macroglobulinaemia proteins. There is evidence to suggest that a proportion of the cross-reactive idiotypes among the anti-Ii antibodies involve this VH antigen.

Entities: Disease Species

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Year: 1977 PMID： 414866 PMCID： PMC1541133

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

27 in total

1. Similar idiotypic specificities in immunoglobulin fractions with different antibody functions or even without detectable antibody function.

Authors: J Oudin; P A Cazenave
Journal: Proc Natl Acad Sci U S A Date: 1971-10 Impact factor: 11.205

2. Cross idiotypic specificity among cold agglutinins in relation to combining activity for blood group-related antigens.

Authors: T Feizi; H G Kunkel; D Roelcke
Journal: Clin Exp Immunol Date: 1974-10 Impact factor: 4.330

3. Bence Jones proteins and light chains of immunoglobulins. IV. Immunochemical differentiation among proteins within each of the three established kappa-chain classes.

Authors: A Solomon; C L McLaughlin
Journal: J Immunol Date: 1971-01 Impact factor: 5.422

4. The covalent structure of an entire gammaG immunoglobulin molecule.

Authors: G M Edelman; B A Cunningham; W E Gall; P D Gottlieb; U Rutishauser; M J Waxdal
Journal: Proc Natl Acad Sci U S A Date: 1969-05 Impact factor: 11.205

5. [The primary structure of a monoclonal IgA-immunoglobulin (IgA Tro.), II. The amino acid sequence of the H-chain, alpha-type, subgroup III; structure of the complete IgA-molecule (author's transl)].

Authors: H Kratzin; P Altevogt; E Ruban; A Kortt; K Staroscik; N Hilschmann
Journal: Hoppe Seylers Z Physiol Chem Date: 1975-08

6. Partial amino acid sequence of an IgA2 human immunoglobulin heavy chain.

Authors: C Wolfenstein-Todel; B Frangione; E C Franklin
Journal: Biochim Biophys Acta Date: 1975-02-27

7. Cross idiotypic specificity among heavy chains of macroglobulins with blood group I and i specificities.

Authors: R Childs; T Feizi
Journal: Nature Date: 1975-06-12 Impact factor: 49.962

8. The switch point in mu heavy chains of human IgM immunoglobulins.

Authors: G Florent; D Lehman; F W Putnam
Journal: Biochemistry Date: 1974-06-04 Impact factor: 3.162

9. [The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), I. The amino acid sequence of the L-chain of kappa-type, subgroup I (author's transl)].

Authors: C J Laure; S Watanabe; N Hilschmann
Journal: Hoppe Seylers Z Physiol Chem Date: 1973 Oct-Nov