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Literature DB >> 4146452

The characterization of two reduced nicotinamide-adenine dinucleotide phosphate-linked aldehyde reductases from pig brain.

Abstract

1. NADPH-linked aldehyde reductase from pig, ox and rat brain exhibits non-linear reciprocal plots when partially purified enzyme preparations are studied. 2. In pig brain this non-linearity is due to the presence of two distinct aldehyde reductases, which can be separated by DEAE-cellulose chromatography. 3. These two enzymes can be distinguished by several criteria, including pH optima, Michaelis constants for substrates and their inhibitor sensitivity. 4. The probable role of these enzymes in the metabolism of the aldehydes derived from the biogenic amines is discussed.

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Year: 1972 PMID： 4146452 PMCID： PMC1174514 DOI： 10.1042/bj1300765

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

20 in total

1. STUDIES ON THE BIOLOGICAL ACTIVITIES OF THE ALDEHYDES DERIVED FROM NOREPINEPHRINE, SEROTONIN, TRYPTAMINE AND HISTAMINE.

Authors: J RENSON; H WEISSBACH; S UDENFRIEND
Journal: J Pharmacol Exp Ther Date: 1964-03 Impact factor: 4.030

2. The metabolism of acetaldehyde by the brain in vivo.

Authors: J W RIDGE
Journal: Biochem J Date: 1963-07 Impact factor: 3.857

3. Diphosphopyridine nucleotide-linked aldehyde dehydrogenase. I. Specificity and sigma-rho function.

Authors: R A DEITRICH; L HELLERMAN; J WEIN
Journal: J Biol Chem Date: 1962-02 Impact factor: 5.157

4. The effect of disulfiram on the metabolism of normetanephrine-1-14C in the guinea pig.

Authors: A A SMITH; S B WORTIS
Journal: Biochem Pharmacol Date: 1960-07 Impact factor: 5.858

5. A micro biuret method for protein determination; determination of total protein in cerebrospinal fluid.

Authors: J GOA
Journal: Scand J Clin Lab Invest Date: 1953 Impact factor: 1.713

6. Amine oxidase and amine metabolism.

Authors: H BLASCHKO
Journal: Pharmacol Rev Date: 1952-12 Impact factor: 25.468

7. Metabolic pathways of dopamine and norepinephrine in rabbit brain in vitro.

Authors: C O Rutledge; J Jonason
Journal: J Pharmacol Exp Ther Date: 1967-09 Impact factor: 4.030

8. Inhibition of aldehyde dehydrogenase by 2-chloroacetophenone and the resultant effects on the catabolism of norepinephrine in brain.

Authors: C O Rutledge; R A Deitrich
Journal: Biochem Pharmacol Date: 1971-01 Impact factor: 5.858

9. Inhibition of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from bovine brain by barbiturates.

Authors: V G Erwin; B Tabakoff; R L Bronaugh
Journal: Mol Pharmacol Date: 1971-03 Impact factor: 4.436

10. Further characterization of a reduced nicotinamide-adenine dinucleotide phosphate-dependent aldehyde reductase from bovine brain. Inhibition by phenothiazine derivatives.

Authors: R L Bronaugh; V G Erwin
Journal: Biochem Pharmacol Date: 1972-05-15 Impact factor: 5.858

13 in total

The characterization of two reduced nicotinamide-adenine dinucleotide phosphate-linked aldehyde reductases from pig brain.

1. STUDIES ON THE BIOLOGICAL ACTIVITIES OF THE ALDEHYDES DERIVED FROM NOREPINEPHRINE, SEROTONIN, TRYPTAMINE AND HISTAMINE.

2. The metabolism of acetaldehyde by the brain in vivo.

3. Diphosphopyridine nucleotide-linked aldehyde dehydrogenase. I. Specificity and sigma-rho function.

4. The effect of disulfiram on the metabolism of normetanephrine-1-14C in the guinea pig.

5. A micro biuret method for protein determination; determination of total protein in cerebrospinal fluid.

6. Amine oxidase and amine metabolism.

7. Metabolic pathways of dopamine and norepinephrine in rabbit brain in vitro.

8. Inhibition of aldehyde dehydrogenase by 2-chloroacetophenone and the resultant effects on the catabolism of norepinephrine in brain.

9. Inhibition of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from bovine brain by barbiturates.

10. Further characterization of a reduced nicotinamide-adenine dinucleotide phosphate-dependent aldehyde reductase from bovine brain. Inhibition by phenothiazine derivatives.

1. Some properties and a suggested reclassification of mevaldate reductase.

2. Purification of the high-Km aldehyde reductase from rat brain and liver and from ox brain.

3. Subcellular localization of aldehyde reductase activities in ox brain.

4. Kinetic studies with the low-Km aldehyde reductase from ox brain.

5. Aldehyde reductase isozymes in the mouse: evidence for two new loci and localization of Ahr-3 on chromosome 7.

6. Mannitol-1-phosphate dehydrogenase of Escherichia coli. Chemical properties and binding of substrates.

7. Simulation of biogenic amine metabolism in the brain.

8. Kinetic studies of the mechanism of pig kidney aldehyde reductase.

9. Purification and characterization of an enzymically active cleavage product of pig kidney aldehyde reductase.

10. Purification and characterization of the multiple forms of aldehyde reductase in ox kidney.