Literature DB >> 4143378

Inhibition of experimental allergic encephalomyelitis in rats severely depleted of T cells.

N K Gonatas, J C Howard.   

Abstract

Lewis rats depleted of thymus-derived cells (B rats) failed to develop either experimental allergic encephalomyelitis or antibody against myelin basic protein. Lewis B rats reconstituted with 690 x 10(6) thymocytes developed experimental allergic encephalomyelitis and levels of antibody against myelin basic protein comparable to those of controls. The Lewis B rat model should be useful in the analysis of the role of thymus-derived cell populations and antibody in the induction of experimental allergic encephalomyelitis.

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Year:  1974        PMID： 4143378     DOI： 10.1126/science.186.4166.839

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  22 in total

Review 1.  Characterization and distribution of lymphocyte subpopulations in multiple sclerosis plaques versus autoimmune demyelinating lesions.

Authors:  U Traugott
Journal:  Springer Semin Immunopathol       Date:  1985

Review 2.  T cell repertoire and autoimmune diseases.

Authors:  L Imberti; A Sottini; D Primi
Journal:  Immunol Res       Date:  1993       Impact factor: 2.829

Review 3.  Cellular basis of T-cell autoreactivity in autoimmune diseases.

Authors:  C Carnaud; J F Bach
Journal:  Immunol Res       Date:  1993       Impact factor: 2.829

4.  T lymphocyte lines in the study of autoimmune disease.

Authors:  H Wekerle; W Fierz
Journal:  Blut       Date:  1984-09

5.  Immunocytochemical localization of the anti-encephalitogenic rat spinal cord protein in neurons, oligodendrocytes and Schwann cells.

Authors:  C F MacPherson; L Bonato
Journal:  Acta Neuropathol       Date:  1983       Impact factor: 17.088

Review 6.  Maintenance of immunologic self-tolerance by nonimmunogenic forms of antigen.

Authors:  R H Swanborg
Journal:  Clin Exp Immunol       Date:  1976-12       Impact factor: 4.330

7.  Immunohistological localization of the anti-encephalitogenic bovine spinal cord protein (BSCP) in axons.

Authors:  C F MacPherson; A C Wallace
Journal:  Acta Neuropathol       Date:  1980       Impact factor: 17.088

8.  Association between susceptibility to experimental allergic encephalomyelitis and the major histocompatibility system in congenic rat strains.

Authors:  E Günther; H Odenthal; W Wechsler
Journal:  Clin Exp Immunol       Date:  1978-06       Impact factor: 4.330

Review 9.  Knocking at the brain's door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures.

Authors:  Naoto Kawakami; Alexander Flügel
Journal:  Semin Immunopathol       Date:  2010-07-11       Impact factor: 9.623

10.  Impairment of cell-mediated immune responses by infection with Mycobacterium lepraemurium.

Authors:  W E Bullock; P E Evans; A R Filomeno
Journal:  Infect Immun       Date:  1977-10       Impact factor: 3.441
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