Literature DB >> 413542

Stimulation of steroid glucuronidation by uridine diphosphate N-acetylglucosamine and by microsomal disruption.

J Wilkinson, T Hallinan.   

Abstract

Glucuronidation of oestrone and of oestradiol in microsomal fractions was markedly and significantly stimulated by UDP-N-acetylglucosamine and by ultrasonication: Triton X-100 also stimulated. This is consistent with compartmentation of UDP-glucuronyl-transferase. Stimulation by UDP-N-acetylglucosamine may be physiologically significant.

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Year:  1977        PMID： 413542      PMCID： PMC1184123          DOI： 10.1042/bj1680125

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  Studies on bilirubin and steroid glucuronidation by rat liver microsomes.

Authors:  M M Jacobson; W Levin; A H Conney
Journal:  Biochem Pharmacol       Date:  1975-03-15       Impact factor: 5.858

2.  Spontaneous and detergent activation of a glucuronyltransferase in vitro.

Authors:  K K Lueders; E L Kuff
Journal:  Arch Biochem Biophys       Date:  1967-04       Impact factor: 4.013

3.  Inhibition of hepatic UDPglucuronyltransferase by nucleotides.

Authors:  A Winsnes
Journal:  Biochim Biophys Acta       Date:  1972-11-10

4.  Summary of a novel, three-component regulatory model for uridine diphosphate glucuronyltransferase.

Authors:  C Berry; T Hallinan
Journal:  Biochem Soc Trans       Date:  1976       Impact factor: 5.407

5.  UDP-glucuronyltransferase in perfused rat liver and in microsomes - III. Effects of galactosamine and carbon tetrachloride on the glucuronidation of 1-naphthol and bilirubin.

Authors:  G Otani; M M Abou-El-Makarem; K W Bock
Journal:  Biochem Pharmacol       Date:  1976-06-01       Impact factor: 5.858

6.  Effects of metals on the properties of hepatic microsomal uridine diphosphate glucuronyltransferase.

Authors:  D Zakim; J Goldenberg; D A Vessey
Journal:  Biochemistry       Date:  1973-10-09       Impact factor: 3.162

7.  Steroid glucuronyltransferases of rat liver. Properties of oestrone and testosterone glucuronyltransferases and the effect of ovariectomy, castration and administration of steroids on the enzymes.

Authors:  G S Rao; G Haueter; M L Rao; H Breuer
Journal:  Biochem J       Date:  1977-03-15       Impact factor: 3.857

8.  The properties of uridine diphosphate glucuronyltransferase(s) which catalyse the synthesis of steroid glucuronides in microsomal fractions from guinea-pig liver.

Authors:  D Zakim; D A Vessey
Journal:  Biochem J       Date:  1976-09-01       Impact factor: 3.857

9.  Guinea pig liver microsomal UDP-glucuronyltransferase: compartmented or phospholipid-constrained?

Authors:  C Berry; A Stellon; T Hallinan
Journal:  Biochim Biophys Acta       Date:  1975-10-22
  9 in total
  1 in total

1.  Diazobenzenesulphonate selectively abolishes stimulation of glucuronidation by UDP-N-acetylglucosamine.

Authors:  B Haeger; R de Brito; T Hallinan
Journal:  Biochem J       Date:  1980-12-15       Impact factor: 3.857
  1 in total

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