Literature DB >> 4132995

Induction of immunological tolerance to a thymus-dependent antigen in the absence of thymus-derived cells.

J W Schrader.   

Abstract

Specific immunological unresponsiveness was induced using thymus-dependent antigens in congenitally athymic (nu/nu) mice, in which no T-cell function has been demonstrated. The tolerance was induced in vivo by the injection of 5-10 mg of either FGG or DNP-HGG. Spleen cells from treated mice were tested in vitro for the ability to mount thymus-independent immune responses against FGG in the presence of polymerized flagellin POL, and the DNP determinant conjugated to POL. A specific deficiency in either the in vitro anti-FGG or anti-DNP response was demonstrated, depending on the antigen used for treatment of the spleen cell donor. Athymic mice treated with FGG were also tested by in vivo challenge with FGG given with POL as an adjuvant and were found to be hyporesponsive. Unresponsiveness to in vitro challenge was established by 24 h after the in vivo injection of FGG. It was found that the injection of POL with the FGG prevented the development of unresponsiveness, but not if the POL was given 24 h or more after the FGG. The unresponsiveness could not be overcome by confrontation with allogeneic spleen cells from CBA mice, although the presence of allogeneic spleen cells had a large amplifying effect on the response of control spleen cells. These experiments demonstrate a mechanism for the tolerization of bone marrow-derived cells by thymus-dependent antigens in the absence of the thymus.

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Year:  1974        PMID: 4132995      PMCID: PMC2139668          DOI: 10.1084/jem.139.5.1303

Source DB:  PubMed          Journal:  J Exp Med        ISSN: 0022-1007            Impact factor:   14.307


  28 in total

1.  Immunological unresponsiveness of genetically thymusless (nude) mice.

Authors:  B Kindred
Journal:  Eur J Immunol       Date:  1971-01       Impact factor: 5.532

Review 2.  Interaction between lymphocytes in immune responses.

Authors:  J F Miller; A Basten; J Sprent; C Cheers
Journal:  Cell Immunol       Date:  1971-10       Impact factor: 4.868

Review 3.  Cooperating and controlling functions of thymus-derived lymphocytes in relation to autoimmunity.

Authors:  A C Allison; A M Denman; R D Barnes
Journal:  Lancet       Date:  1971-07-17       Impact factor: 79.321

4.  Induction of immunity and tolerance to the dinitrophenyl determinant in vitro.

Authors:  M Feldmann
Journal:  Nat New Biol       Date:  1971-05-05

5.  The immune response of normal, irradiated and thymectomized mice to fowl immunoglobulin G as detected by a hemolytic plaque technique.

Authors:  J F Miller; N L Warner
Journal:  Int Arch Allergy Appl Immunol       Date:  1971

6.  Use of an antiglobulin serum to detect cells producing antibody with low haemolytic efficiency.

Authors:  D W Dresser; D H Wortis
Journal:  Nature       Date:  1965-11-27       Impact factor: 49.962

7.  Infectious immunological tolerance.

Authors:  R K Gershon; K Kondo
Journal:  Immunology       Date:  1971-12       Impact factor: 7.397

8.  A theory of self-nonself discrimination.

Authors:  P Bretscher; M Cohn
Journal:  Science       Date:  1970-09-11       Impact factor: 47.728

9.  The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.

Authors:  M Feldmann; A Easten
Journal:  J Exp Med       Date:  1971-07-01       Impact factor: 14.307

10.  Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates.

Authors:  D H Katz; J M Davie; W E Paul; B Benacerraf
Journal:  J Exp Med       Date:  1971-07-01       Impact factor: 14.307

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  12 in total

Review 1.  Current perspectives on the cellular mechanisms of immunologic tolerance.

Authors:  D E Parks; W O Weigle
Journal:  Clin Exp Immunol       Date:  1980-02       Impact factor: 4.330

2.  Tolerance induction in TxXBT and TxXB mice.

Authors:  S Muramatsu; T Amagai; Y Katura
Journal:  Immunology       Date:  1975-05       Impact factor: 7.397

3.  Tolerance induction during ontogeny. I. Presence of active suppression in mice rendered tolerant to human gamma-globulin in utero correlates with the breakdown of the tolerant state.

Authors:  C A Waters; L M Pilarski; T G Wegmann; E Diener
Journal:  J Exp Med       Date:  1979-05-01       Impact factor: 14.307

4.  Induction and mode of action of suppressor cells generated against human gamma globulin. II. Effects of colchicine.

Authors:  D E Parks; D A Shaller; W O Weigle
Journal:  J Exp Med       Date:  1979-05-01       Impact factor: 14.307

5.  Evidence for the clonal abortion theory of B-lymphocyte tolerance.

Authors:  G J Nossal; B L Pike
Journal:  J Exp Med       Date:  1975-04-01       Impact factor: 14.307

6.  Effector cell blockade. A new mechanism of immune hyporeactivity induced by multivalent antigens.

Authors:  J W Schrader; G J Nossal
Journal:  J Exp Med       Date:  1974-06-01       Impact factor: 14.307

7.  The allogeneic bisection of carrier-specific enhancement of monoclonal B-cell responses.

Authors:  S K Pierce; N R Klinman
Journal:  J Exp Med       Date:  1975-11-01       Impact factor: 14.307

8.  Deregulation of idiotype expression. Induction of tolerance in an anti-idiotypic response.

Authors:  L Ortiz-Ortiz; W O Weigle; D E Parks
Journal:  J Exp Med       Date:  1982-09-01       Impact factor: 14.307

9.  The in vitro induction of immunological tolerance in the B lymphocyte by oligovalent thymus-dependent antigens.

Authors:  J W Schrader
Journal:  J Exp Med       Date:  1975-05-01       Impact factor: 14.307

10.  Immunologic responsiveness of the C3H/HeJ mouse: differential ability of butanol-extracted lipopolysaccharide (LPS) to evoke LPS-mediated effects.

Authors:  M G Goodman; D E Parks; W O Weigle
Journal:  J Exp Med       Date:  1978-03-01       Impact factor: 14.307

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