Literature DB >> 413192

Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract.

H H Schaumburg, P S Spencer.   

Abstract

2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.

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Year:  1978        PMID： 413192     DOI： 10.1126/science.413192

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  20 in total

1.  Neuroendocrine effects in printing workers exposed to toluene.

Authors:  B G Svensson; G Nise; E M Erfurth; H Olsson
Journal:  Br J Ind Med       Date:  1992-06

2.  Neurotoxic effects of n-hexane on the human central nervous system: evoked potential abnormalities in n-hexane polyneuropathy.

Authors:  Y C Chang
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-03       Impact factor: 10.154

Review 3.  Neuroprotein Targets of γ-Diketone Metabolites of Aliphatic and Aromatic Solvents That Induce Central-Peripheral Axonopathy.

Authors:  Peter S Spencer
Journal:  Toxicol Pathol       Date:  2020-03-12       Impact factor: 1.902

4.  Morphologic changes induced in vitro by 2,5 hexanedione.

Authors:  W Malorni; G Formisano; G Donelli
Journal:  In Vitro Cell Dev Biol       Date:  1989-01

5.  N-hexane maculopathy in industrial workers.

Authors:  C Raitta; A N Seppäläinen; M S Huuskonen
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1978-12-15

6.  n-Hexane-induced changes in nerve conduction velocities and somatosensory evoked potentials.

Authors:  A Mutti; F Ferri; G Lommi; S Lotta; S Lucertini; I Franchini
Journal:  Int Arch Occup Environ Health       Date:  1982       Impact factor: 3.015

7.  Neurotoxicity of acrylamide and related compounds in rats. Effects on rotarod performance, morphology of nerves and neurotubulin.

Authors:  H Tanii; K Hashimoto
Journal:  Arch Toxicol       Date:  1983-11       Impact factor: 5.153

8.  Acquired Color Vision Defects and Hexane Exposure: A Study of San Francisco Bay Area Automotive Mechanics.

Authors:  Stella Beckman; Ellen A Eisen; Michael N Bates; Sa Liu; Gunilla Haegerstrom-Portnoy; S Katharine Hammond
Journal:  Am J Epidemiol       Date:  2016-05-17       Impact factor: 4.897

9.  Solvent related colour vision loss: an indicator of neural damage?

Authors:  D Mergler; L Blain; J P Lagacé
Journal:  Int Arch Occup Environ Health       Date:  1987       Impact factor: 3.015

10.  A comparative study on the neurotoxicity of n-pentane, n-hexane, and n-heptane in the rat.

Authors:  Y Takeuchi; Y Ono; N Hisanaga; J Kitoh; Y Sugiura
Journal:  Br J Ind Med       Date:  1980-08
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