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Literature DB >> 4131500

Evaluation of dimethylhydrazine induced tumours in mice as a model system for colorectal cancer.

P Haase, D M Cowen, J C Knowles, E H Cooper.

Abstract

The evolution and structure of adenomatous polyps and adenocarcinomata of the colon in NMRI mice induced by dimethylhydrazine are described. Severe toxic reactions in the liver and other organs are produced by dimethylhydrazine (DMH), but tumours are induced only in the colon and around the anus. The 100% incidence and growth characteristics of the tumours make it potentially a good model system, but investigators should take into account the widespread nonspecific cellular injury induced by this carcinogen.

Entities: Chemical Disease Species

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Year: 1973 PMID： 4131500 PMCID： PMC2008945 DOI： 10.1038/bjc.1973.183

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

11 in total

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19 in total

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Authors: Ulrich Bork; Robert Grützmann; Nuh N Rahbari; Sebastian Schölch; Marius Distler; Christoph Reissfelder; Moritz Koch; Jürgen Weitz
Journal: World J Gastroenterol Date: 2014-08-14 Impact factor: 5.742

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Authors: Fereshteh Ezzati Ghadi; Anshoo Malhotra; Abdollah Ramzani Ghara; D K Dhawan
Journal: Mol Cell Biochem Date: 2012-07-01 Impact factor: 3.396