Literature DB >> 4127121

Uridine kinase in embryonic rat liver. Modulation of enzyme activity by 5-azacytidine.

J Veselý, A Cihák.   

Abstract

Uridine kinase activity in rat liver decreases during embryonic and postnatal development. Administration of 5-azacytidine enhances liver uridine kinase activity in adult rats, but depresses it in embryos. The liver enzymes from the foetus and the adult are precipitated at different (NH(4))(2)SO(4) concentrations although they are eluted at about the same position on chromatography on a column of Sepharose 6B.

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Year:  1973        PMID： 4127121      PMCID： PMC1177749          DOI： 10.1042/bj1330609d

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  Multiple forms of uridine kinase in normal and neoplastic rat liver.

Authors:  G Krystal; T E Webb
Journal:  Biochem J       Date:  1971-10       Impact factor: 3.857

2.  Activity and distribution of the enzymes of uridylate synthesis from orotate in animal tissues.

Authors:  J Pausch; D Keppler; K Decker
Journal:  Biochim Biophys Acta       Date:  1972-02-28

3.  Enhanced uridine kinase and RNA synthesis in regenerating rat liver after 5-azacytidine administration.

Authors:  A Cihàk; M Seifertovà; J Veselỳ
Journal:  Arch Biochem Biophys       Date:  1972-02       Impact factor: 4.013

4.  Properties of thymidine kinase partially purified from human fetal and adult tissue.

Authors:  A T Taylor; M A Stafford; O W Jones
Journal:  J Biol Chem       Date:  1972-03-25       Impact factor: 5.157

5.  Enhanced stability of uridine kinase from mouse leukemic cells resistant to 5-azacytidine. Thermal inactivation and effect of p-chloromercuribenzoate.

Authors:  J Veselý; A Cihák; F Sorm
Journal:  Eur J Biochem       Date:  1971-10-26

6.  Cerebral cortex of the mouse after prenatal chemical insult.

Authors:  J Langman; M Shimada
Journal:  Am J Anat       Date:  1971-11

7.  Association of decreased uridine and deoxycytidine kinase with enhanced RNA and DNA polymerase in mouse leukemic cells resistant to 5-azacytidine and 5-aza-2'-deoxycytidine.

Authors:  J Veselý; A Cihák; F Sorm
Journal:  Cancer Res       Date:  1970-08       Impact factor: 12.701

8.  Effect of combination treatment with 5-azacytidine and cytidine on the life-span and spleen and bone marrow cells of leukemic (L1210) and nonleukemic mice.

Authors:  S Vadlamudi; J N Choudry; V S Waravdekar; I Kline; A Goldin
Journal:  Cancer Res       Date:  1970-02       Impact factor: 12.701

9.  Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor.

Authors:  A Orengo
Journal:  J Biol Chem       Date:  1969-04-25       Impact factor: 5.157

10.  Partial reversal of toxic effects of 5-azacytidine by 6-azauridine in normal mice.

Authors:  F Sorm; J Veselý
Journal:  Experientia       Date:  1965-10-15
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  1 in total

Review 1.  Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases.

Authors:  An R Van Rompay; Magnus Johansson; Anna Karlsson
Journal:  Pharmacol Ther       Date:  2003-11       Impact factor: 12.310
  1 in total

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