| Literature DB >> 412623 |
D P Chakraborty, S K Chowdhury, R N Dey, A Chatterjee.
Abstract
Tryptophan pyrrolase, a microsomal enzyme responsible for the break-down of tryptophan, has been detected in Bufo melanostictus. The enzyme has been found to be deactivated under influence of antivitiligo drug psoralene and activated by hydroquinone, an inhibitor of tyrosinase. Tryptophan pyrrolase has been found to have an antagonistic relationship with tyrosinase in Bufo melanostictus. The implication of the results has been discussed in relation to melanogenesis in vitiligo.Entities:
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Year: 1978 PMID： 412623 DOI： 10.1016/0009-8981(78)90025-6
Source DB: PubMed Journal: Clin Chim Acta ISSN： 0009-8981 Impact factor: 3.786