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Literature DB >> 4123071

Genetic model for the Rh blood-group system.

R E Rosenfield, F H Allen, P Rubinstein.

Abstract

Inherited quantitative aspects of the Rh blood-group system and susceptibility of Rh to the effects of independently segregating suppressor genes can be accounted for with a conjugated operon model. This assumes the existence of four operator or promotor (control) genes for these functions, while closely linked structural regions determine the qualitative characteristics of Rh antigens. Observed restriction of antigenic crossreactivity to the products of adjacent genetic regions and data from blood typing of nonhuman primates both suggest that Rh complexity arose from a series of gene duplications and independent mutations.

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Year: 1973 PMID： 4123071 PMCID： PMC433484 DOI： 10.1073/pnas.70.5.1303

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

40 in total

1. Reaction of I-131 trace labeled human anti-Rho(D) with red cells.

Authors: S P MASOUREDIS
Journal: J Clin Invest Date: 1959-02 Impact factor: 14.808

2. Studies on papain produced subunits of human gamma-G-globulins. II. Structures of peptides related to the genetic Gm activity of gamma-G-globulin Fc-fragments.

Authors: N O Thorpe; H F Deutsch
Journal: Immunochemistry Date: 1966-07

Genetic model for the Rh blood-group system.

1. Reaction of I-131 trace labeled human anti-Rho(D) with red cells.

2. Studies on papain produced subunits of human gamma-G-globulins. II. Structures of peptides related to the genetic Gm activity of gamma-G-globulin Fc-fragments.

3. A new cause of haemolytic anaemia?

4. Hematological observations on the anemia associated with blood type Rhnull.

5. Erythrocyte membrane sulfhydryl groups and Rh antigen activity.

6. Evidence for a mutation or crossing-over at the Rh locus.

7. An Rh gene complex which results in a "new" antigen detectable by a specific antibody, Anti-Rh 33.

8. Transient production of anti-LW by LW-positive people.

9. Quantitative two-dimensional ultrastructural distribution of Rh o (D) antigenic sites on human erythrocyte membranes.

10. The fluid mosaic model of the structure of cell membranes.

Review 1. Toward universal donor blood: Enzymatic conversion of A and B to O type.

Review 2. Pyroptosis versus necroptosis: similarities, differences, and crosstalk.