| Literature DB >> 4122422 |
Abstract
Each of six mammalian C-type viruses-including two feline leukemia viruses, three murine leukemia viruses, and the human "candidate" virus RD-114-can be distinguished from each other by hybridizing DNA synthesized by viral reverse transcriptase with viral RNA. Characterization of the DNA . RNA hybrids by hydroxylapatite chromatography revealed nucleotide sequence diversity among the viruses, detectable both by the amount of cross-hybridization and by the decreased thermal stability of heterologous hybrids.Entities:
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Year: 1973 PMID: 4122422 DOI: 10.1126/science.180.4089.972
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728