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Literature DB >> 412217

Kinetics of distribution of amphetamine in cats.

R Latini, G F Placidi, E Riva, P Fornaro, M Guarneri, P L Morselli.

Abstract

The distribution and metabolic fate of amphetamine were studied in cats. In the brain, high levels of drug were detected in the grey matter structures at short intervals after administration, while at longer intervals distribution between white and grey matter areas was more uniform. In peripheral tissues the greatest concentration of the drug was seen in the highly vascularized organs. Para-hydroxy-amphetamine was found in minimal amounts in the liver and kidneys and only at trace quantities in the brain.

Entities: Chemical Species

Mesh：

Substances：
Amphetamine

Year: 1977 PMID： 412217 DOI： 10.1007/bf00426782

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

16 in total

Kinetics of distribution of amphetamine in cats.

1. Sulfur-35 labeled acetazolamide in cat brain.

2. Studies on the distribution and fate of S35-labelled benzylpenicillin in the body.

3. Application of quantitative GC-mass spectrometry to study of pharmacokinetics of amphetamine and phentermine.

4. Extent of plasma protein binding of amphetamine in different species.

5. Effect of some drugs on free fatty acids and triglycerides in plasma and tissues.

6. Gas chromatographic determination of amphetamine in blood, tissue, and urine.

7. Caudal dopamine and stereotype behaviour of cats.

8. Measurement of regional cerebral blood flow with antipyrine-14C in awake cats.

9. Distribution of amphetamine and its hydroxylated metabolites in various areas of the rat brain.

Review 1. Clinical pharmacology of the perinatal period and early infancy.