Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The development of tolerance to morphine in the rat.

Literature DB >> 412215

The development of tolerance to morphine in the rat.

Abstract

Tolerance to various effects of morphine in the rat can be quantified by means of a shift of semi-logarithmic dose-response curves. Tolerance to analgesia (hot plate, acetic acid writhing), catalepsy, and the tilted plane develops in a closely similar manner. Also, the stimulating effects of about 1 mg/kg morphine-HC1 tested in an open-field procedure are somewhat less pronounced in chronically treated rats than in naive ones. There is no correlation between tolerance development and the acute ED50 of different tests.

Entities: Chemical Disease Species

Mesh：

Substances：
Morphine

Year: 1977 PMID： 412215 DOI： 10.1007/bf00426780

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

1 in total

1. Behavioural and pharmacological studies on morphine-induced excitation of rats. Possible relation to brain catecholamines.

Authors: I H Ayhan; A Randrup
Journal: Psychopharmacologia Date: 1973

1 in total

12 in total

1. Associative and behavioral tolerance to the analgesic effects of nicotine in rats: tail-flick and paw-lick assays.

Authors: Antonio Cepeda-Benito; Kristina W Davis; Jose T Reynoso; James H Harraid
Journal: Psychopharmacology (Berl) Date: 2005-02-05 Impact factor: 4.530

2. In vivo apparent pA2 analysis in rats treated with either clocinnamox or morphine.

Authors: E A Walker; T M Richardson; A M Young
Journal: Psychopharmacology (Berl) Date: 1996-05 Impact factor: 4.530

3. Tolerance and dependence after continuous morphine infusion from osmotic pumps measured by operant responding in rats.

Authors: J U Adams; S G Holtzman
Journal: Psychopharmacology (Berl) Date: 1990 Impact factor: 4.530

The development of tolerance to morphine in the rat.

1. Behavioural and pharmacological studies on morphine-induced excitation of rats. Possible relation to brain catecholamines.

1. Associative and behavioral tolerance to the analgesic effects of nicotine in rats: tail-flick and paw-lick assays.

2. In vivo apparent pA2 analysis in rats treated with either clocinnamox or morphine.

3. Tolerance and dependence after continuous morphine infusion from osmotic pumps measured by operant responding in rats.

4. Development and loss of tolerance to morphine in the rat.

5. Tolerance to hyperthermia produced by morphine in rat.

6. Differential tolerance to morphine antinociception in assays of pain-stimulated vs. pain-depressed behavior in rats.

7. Biotelemetric investigation of morphine's thermic and kinetic effects in rats.

8. Cross-tolerance of associative and nonassociative morphine tolerance in the rat with mu- and kappa-specific opioids.

9. Oxytocin diminishes heroin tolerance in mice.

10. Morphine-conditioned analgesia using a taste cue: dissociation of taste aversion and analgesia.