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Literature DB >> 4121700

Purification and biophysical characterization of hepatitis B antigen.

Abstract

Hepatitis B antigen (HB Ag) has been purified from serum by pepsin digestion and equilibrium sedimentation. The sedimentation coefficient, density, particle size, and electrophoretic mobility have been determined before and after purification and found to be unaltered. In addition, the diffusion constant and molecular weight of purified HB Ag have been documented. Because the biophysical characteristics found are not consistant with those of any known virus, it is believed that native HB Ag is made up almost entirely of incomplete virus.

Entities: Disease

Mesh：

Substances：

Year: 1973 PMID： 4121700 PMCID： PMC302373 DOI： 10.1172/JCI107284

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

22 in total

1. Particles associated with Australia antigen in the sera of patients with leukaemia, Down's Syndrome and hepatitis.

Authors: M E Bayer; B S Blumberg; B Werner
Journal: Nature Date: 1968-06-15 Impact factor: 49.962

2. A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis.

Authors: B S Blumberg; B J Gerstley; D A Hungerford; W T London; A I Sutnick
Journal: Ann Intern Med Date: 1967-05 Impact factor: 25.391

3. Australia antigen and viral hepatitis.

Authors: R M Kater; C Y Kim; C S Davidson
Journal: J Infect Dis Date: 1969-09 Impact factor: 5.226

4. Virus-like particles in sera of patients with infectious and serum hepatitis.

Authors: R J Hirschman; N R Shulman; L F Barker; K O Smith
Journal: JAMA Date: 1969-06-02 Impact factor: 56.272

5. Virus-like particles in serum of patients with Australia-antigen-associated hepatitis.

Authors: D S Dane; C H Cameron; M Briggs
Journal: Lancet Date: 1970-04-04 Impact factor: 79.321

6. Immune complexes in hepatitis.

Authors: J D Almeida; A P Waterson
Journal: Lancet Date: 1969-11-08 Impact factor: 79.321

7. An antigen detected in the blood during the incubation period of serum hepatitis.

Authors: A M Prince
Journal: Proc Natl Acad Sci U S A Date: 1968-07 Impact factor: 11.205

8. Biophysical properties of Australia antigen.

Authors: J L Gerin; R H Purcell; M D Hoggan; P V Holland; R M Chanock
Journal: J Virol Date: 1969-11 Impact factor: 5.103

9. Some antigenic and physical properties of virus-like particles in sera of hepatitis patients.

Authors: L F Barker; K O Smith; W D Gehle; N R Shulman
Journal: J Immunol Date: 1969-06 Impact factor: 5.422

10. Further studies on a "new" human isoprecipitin system (Australia antigen).

Authors: H J Alter; B S Blumberg
Journal: Blood Date: 1966-03 Impact factor: 22.113

13 in total

1. Biophysical properties and morphology of purified antigen associated with non-A, non-B hepatitis.

Authors: O Spertini; P C Frei
Journal: Med Microbiol Immunol Date: 1986 Impact factor: 3.402

2. Partial amino acid sequence of two major component polypeptides of hepatitis B surface antigen.

Authors: D L Peterson; I M Roberts; G N Vyas
Journal: Proc Natl Acad Sci U S A Date: 1977-04 Impact factor: 11.205

3. Extrahepatic manifestations of hepatitis B virus infection: Addison's disease and myelofibrosis in a patient with persistent hepatitis B surface antigenemia.

Authors: F Somlo; G R Berry
Journal: Can J Infect Dis Date: 1993-05

Purification and biophysical characterization of hepatitis B antigen.

1. Particles associated with Australia antigen in the sera of patients with leukaemia, Down's Syndrome and hepatitis.

2. A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis.

3. Australia antigen and viral hepatitis.

4. Virus-like particles in sera of patients with infectious and serum hepatitis.

5. Virus-like particles in serum of patients with Australia-antigen-associated hepatitis.

6. Immune complexes in hepatitis.

7. An antigen detected in the blood during the incubation period of serum hepatitis.

8. Biophysical properties of Australia antigen.

9. Some antigenic and physical properties of virus-like particles in sera of hepatitis patients.

10. Further studies on a "new" human isoprecipitin system (Australia antigen).

1. Biophysical properties and morphology of purified antigen associated with non-A, non-B hepatitis.

2. Partial amino acid sequence of two major component polypeptides of hepatitis B surface antigen.

3. Extrahepatic manifestations of hepatitis B virus infection: Addison's disease and myelofibrosis in a patient with persistent hepatitis B surface antigenemia.

4. Editorial: Australia antigen updated.

5. [Virus-induced liver diseases in man. III. Chronic hepatitis].

Review 6. The immunopathology of acute type B hepatitis.

Review 7. The hepatitis B virus and its DNA polymerase: the prototype three-D virus.

Review 8. Immunobiology and pathogenesis of hepatitis B virus infection.

9. Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection.

10. Hepatitis B surface antigen assembles in a post-ER, pre-Golgi compartment.