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Literature DB >> 4118975

Early clinical experience with bleomycin in the United Kingdom in series of 105 patients.

K E Halnan, N M Bleehen, T B Brewin, T J Deeley, D F Harrison, C Howland, P B Kunkler, G L Ritchie, E Wiltshaw, I D Todd.

Abstract

The results of treating a series of 105 patients (79 with advanced squamous cell carcinoma, 21 with advanced lymphoma, and 5 with miscellaneous tumours) with bleomycin are described. The drug was usually given as a single agent. Four patients with squamous cell carcinoma showed complete regression and there was partial regression in 25. Side effects were frequent, particularly skin changes and stomatitis; death from pneumonitis occurred in one patient.

Entities: Chemical Disease Species

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Year: 1972 PMID： 4118975 PMCID： PMC1786940 DOI： 10.1136/bmj.4.5841.635

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

8 in total

1. Effectiveness of high-dose infusions of methotrexate followed by leucovorin in carcinoma of the head and neck.

Authors: M S Mitchell; N W Wawro; R C DeConti; S R Kaplan; R Papac; J R Bertino
Journal: Cancer Res Date: 1968-06 Impact factor: 12.701

2. [Clinical experience with bleomycin--a new cytostatic agent for cancer].

Authors: H Host; P Berdal; I O Brennhovd; T Ekroll
Journal: Tidsskr Nor Laegeforen Date: 1971-04-10

3. Bleomycin treatment of the tumors of penis and scrotum.

Authors: T Ichikawa; I Nakano; I Hirokawa
Journal: J Urol Date: 1969-12 Impact factor: 7.450

4. [Roentgenological lung changes during bleomycin treatment].

Authors: J Jorgensen
Journal: Ugeskr Laeger Date: 1971-02-26

5. [Bleomycin. A preliminary report on a new antitumor antibiotic].

Authors: J Rygård; H S Hansen; K B Jensen; J Aastrup; S J Jorgensen; M Blichert-Toft; T Floystrup; A Gerlith
Journal: Ugeskr Laeger Date: 1971-02-26

6. New antibiotics, bleomycin A and B.

Authors: H Umezawa; K Maeda; T Takeuchi; Y Okami
Journal: J Antibiot (Tokyo) Date: 1966-09 Impact factor: 2.649

7. Sequential chemotherapy and radiotherapy. Preliminary results of clinical trial with methotrexate in head and neck cancer.

Authors: M M Kligerman; S Hellman; J R Bertino; C F Von Essen
Journal: Radiology Date: 1966-02 Impact factor: 11.105

8. The potentiation of radiation effects with 5-fluoro-uracil.

Authors: L V FOYE; F M WILLETT; B HALL; M ROTH
Journal: Calif Med Date: 1960-11

8 in total

6 in total

Early clinical experience with bleomycin in the United Kingdom in series of 105 patients.

1. Effectiveness of high-dose infusions of methotrexate followed by leucovorin in carcinoma of the head and neck.

2. [Clinical experience with bleomycin--a new cytostatic agent for cancer].

3. Bleomycin treatment of the tumors of penis and scrotum.

4. [Roentgenological lung changes during bleomycin treatment].

5. [Bleomycin. A preliminary report on a new antitumor antibiotic].

6. New antibiotics, bleomycin A and B.

7. Sequential chemotherapy and radiotherapy. Preliminary results of clinical trial with methotrexate in head and neck cancer.

8. The potentiation of radiation effects with 5-fluoro-uracil.

1. Fatal pneumothorax associated with bleomycin-induced pulmonary fibrosis.

2. Combined chemotherapy with bleomycin, adriamycin, and platinum in advanced thyroid cancer.

3. Chemotherapy of thyroid carcinoma.

4. Hyperpigmentation after bleomycin therapy. Ultrastructural study.

5. Effectiveness and Safety of Pegfilgrastim in BEP Treatment for Patients with Germ Cell Tumor.

6. Combined effects of bleomycin and X-rays on DNA synthesis in asynchronous Ehrlich ascites cells in suspension.