Literature DB >> 4118259

Australia antigen (hepatitis B antigen): a conformational antigen dependent on disulfide bonds.

G N Vyas, K R Rao, A B Ibrahim.   

Abstract

Reduction and alkylation of purified hepatitis-associated Australia antigen (hepatitis B antigen) resulted in a total loss of serologic activity. The reduced and alkylated protein formed a single band with a sedimentation coefficient of 31S on analytical ultracentrifugation, and no subunits were detected by Sephadex gel filtration. Although this preparation induced a delayed hypersensitivity response when injected into guinea pigs, it failed to stimulate humoral antibody formation. The data suggest that hepatitis B antigen is a conformational antigen critically dependent upon the disulfide bonds of the protein moiety.

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Year:  1972        PMID： 4118259     DOI： 10.1126/science.178.4067.1300

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  22 in total

1.  Cell-mediated immunity in guinea pigs to subunits derived from hepatitis B surface antigen.

Authors:  G A Cabral; R Chairez; F Marciano-Cabral; M Suarez; G R Dreesman; J L Melnick; F B Hollinger
Journal:  Infect Immun       Date:  1975-09       Impact factor: 3.441

2.  The amino Acid residues at positions 120 to 123 are crucial for the antigenicity of hepatitis B surface antigen.

Authors:  Yongjun Tian; Yang Xu; Zhenhua Zhang; Zhongji Meng; Li Qin; Mengji Lu; Dongliang Yang
Journal:  J Clin Microbiol       Date:  2007-07-03       Impact factor: 5.948

3.  Identification of hepatitis B virus polypeptides encoded by the entire pre-s open reading frame.

Authors:  D T Wong; N Nath; J J Sninsky
Journal:  J Virol       Date:  1985-07       Impact factor: 5.103

4.  Biochemical and biophysical characterization of maize-derived HBsAg for the development of an oral vaccine.

Authors:  Shweta Shah; Celine A Hayden; Maria E Fischer; A Gururaj Rao; John A Howard
Journal:  Arch Biochem Biophys       Date:  2015-10-28       Impact factor: 4.013

5.  Partial amino acid sequence of two major component polypeptides of hepatitis B surface antigen.

Authors:  D L Peterson; I M Roberts; G N Vyas
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

6.  Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen.

Authors:  B E Eble; D R MacRae; V R Lingappa; D Ganem
Journal:  Mol Cell Biol       Date:  1987-10       Impact factor: 4.272

7.  Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles.

Authors:  R A Lerner; N Green; H Alexander; F T Liu; J G Sutcliffe; T M Shinnick
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

8.  Structural relationships between the surface antigens of ground squirrel hepatitis virus and human hepatitis B virus.

Authors:  W H Gerlich; M A Feitelson; P L Marion; W S Robinson
Journal:  J Virol       Date:  1980-12       Impact factor: 5.103

9.  Participating in the evolution of transfusion medicine from a dispensary into a discipline.

Authors:  Girish N Vyas
Journal:  Transfus Med Rev       Date:  2008-04

10.  Entry of hepatitis delta virus requires the conserved cysteine residues of the hepatitis B virus envelope protein antigenic loop and is blocked by inhibitors of thiol-disulfide exchange.

Authors:  Georges Abou-Jaoudé; Camille Sureau
Journal:  J Virol       Date:  2007-09-26       Impact factor: 5.103
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