Literature DB >> 411778

Homocitrate synthase as the crucial site of the lysine effect on penicillin biosynthesis.

C G Friedrich, A L Demain.   

Abstract

Homocitrate reverses the lysine inhibition of penicillin bisynthesis. Since lysine is known to inhibit homocitrate synthase, reversal by the reaction product identifies this enzyme as the crucial site of the lysine effect.

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Year:  1977        PMID： 411778     DOI： 10.7164/antibiotics.30.760

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

Review 1.  Control of antibiotic biosynthesis.

Authors:  J F Martin; A L Demain
Journal:  Microbiol Rev       Date:  1980-06

2.  Uptake and metabolism of alpha-aminoadipic acid by Penicillium chrysogenum Wis 54-1255.

Authors:  C G Friedrich; A L Demain
Journal:  Arch Microbiol       Date:  1978-10-04       Impact factor: 2.552

3.  Unexpected enhancement of beta-lactam antibiotic formation in Streptomyces clavuligerus by very high concentrations of exogenous lysine.

Authors:  A Fang; P Keables; A L Demain
Journal:  Appl Microbiol Biotechnol       Date:  1996-02       Impact factor: 4.813

Review 4.  Molecular regulation of beta-lactam biosynthesis in filamentous fungi.

Authors:  A A Brakhage
Journal:  Microbiol Mol Biol Rev       Date:  1998-09       Impact factor: 11.056

5.  Uptake of the beta-lactam precursor alpha-aminoadipic acid in Penicillium chrysogenum is mediated by the acidic and the general amino acid permease.

Authors:  Hein Trip; Melchior E Evers; Jan A K W Kiel; Arnold J M Driessen
Journal:  Appl Environ Microbiol       Date:  2004-08       Impact factor: 4.792

6.  Regulation of cephamycin C synthesis, aspartokinase, dihydrodipicolinic acid synthetase, and homoserine dehydrogenase by aspartic acid family amino acids in Streptomyces clavuligerus.

Authors:  S Mendelovitz; Y Aharonowitz
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191

7.  Inhibition and repression of homocitrate synthase by lysine in Penicillium chrysogenum.

Authors:  J M Luengo; G Revilla; M J López; J R Villanueva; J F Martín
Journal:  J Bacteriol       Date:  1980-12       Impact factor: 3.490
  7 in total

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