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Literature DB >> 4117771

Stimulated normal human lymphocytes contain a ribonuclease-sensitive DNA polymerase distinct from viral RNA-directed DNA polymerase.

S N Bobrow, R G Smith, M S Reitz, R C Gallo.

Abstract

Ribonuclease-sensitive DNA synthesis is demonstrated in a cytoplasmic particulate fraction of normal human blood lymphocytes stimulated with phytohemagglutinin, but not in unstimulated lymphocytes. DNA polymerase purified from this fraction does not transcribe the heteropolymeric regions of 70S RNA from RNA tumor viruses, thus distinguishing this enzyme from the RNA-directed DNA polymerase (reverse transcriptase) found in oncogenic RNA viruses and human leukemic cells.

Entities: Disease Species

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Year: 1972 PMID： 4117771 PMCID： PMC389742 DOI： 10.1073/pnas.69.11.3228

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

1. Inhibitors of the RNA and DNA dependent polymerase activities of RNA tumour viruses.

Authors: C Gurgo; R K Ray; L Thiry; M Green
Journal: Nat New Biol Date: 1971-01-27

2. DNA polymerases of Rous sarcoma virus: delineation of two reactions with actinomycin.

Authors: J P McDonnell; A C Garapin; W E Levinson; N Quintrell; L Fanshier; J M Bishop
Journal: Nature Date: 1970-10-31 Impact factor: 49.962

3. RNA-dependent DNA polymerase in virions of RNA tumour viruses.

Authors: D Baltimore
Journal: Nature Date: 1970-06-27 Impact factor: 49.962

4. RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

Authors: H M Temin; S Mizutani
Journal: Nature Date: 1970-06-27 Impact factor: 49.962

5. Synthesis of amplified DNA that codes for ribosomal RNA.

Authors: M Crippa; G P Tocchini-Valentini
Journal: Proc Natl Acad Sci U S A Date: 1971-11 Impact factor: 11.205

6. Ribonuclease H. An enzyme degrading the RNA moiety of DNA-RNA hybrids.

Authors: P Hausen; H Stein
Journal: Eur J Biochem Date: 1970-06

7. RNA dependent DNA synthesis in cell free preparations of human leukemia cells.

Authors: W W Ackermann; W H Murphy; B A Miller; H Kurtz; S T Barker
Journal: Biochem Biophys Res Commun Date: 1971-02-19 Impact factor: 3.575

8. RNA dependent DNA polymerase of human acute leukaemic cells.

Authors: R C Gallo; S S Yang; R C Ting
Journal: Nature Date: 1970-12-05 Impact factor: 49.962

9. A possible role for RNA polymerase in the initiation of M13 DNA synthesis.

Authors: D Brutlag; R Schekman; A Kornberg
Journal: Proc Natl Acad Sci U S A Date: 1971-11 Impact factor: 11.205

10. Primer requirement and template specificity of the DNA polymerase of RNA tumor viruses.

Authors: D Baltimore; D Smoler
Journal: Proc Natl Acad Sci U S A Date: 1971-07 Impact factor: 11.205

15 in total

1. Cytology of rheumatoid synovial cells in culture. IV. Further investigations of cell lines cocultivated with rheumatoid synovial cells.

Authors: M Norval; A Graham; B P Marmion
Journal: Ann Rheum Dis Date: 1976-08 Impact factor: 19.103

Stimulated normal human lymphocytes contain a ribonuclease-sensitive DNA polymerase distinct from viral RNA-directed DNA polymerase.

1. Inhibitors of the RNA and DNA dependent polymerase activities of RNA tumour viruses.

2. DNA polymerases of Rous sarcoma virus: delineation of two reactions with actinomycin.

3. RNA-dependent DNA polymerase in virions of RNA tumour viruses.

4. RNA-dependent DNA polymerase in virions of Rous sarcoma virus.

5. Synthesis of amplified DNA that codes for ribosomal RNA.

6. Ribonuclease H. An enzyme degrading the RNA moiety of DNA-RNA hybrids.

7. RNA dependent DNA synthesis in cell free preparations of human leukemia cells.

8. RNA dependent DNA polymerase of human acute leukaemic cells.

9. A possible role for RNA polymerase in the initiation of M13 DNA synthesis.

10. Primer requirement and template specificity of the DNA polymerase of RNA tumor viruses.

1. Cytology of rheumatoid synovial cells in culture. IV. Further investigations of cell lines cocultivated with rheumatoid synovial cells.

2. Endogenous DNA-directed DNA synthesising system in a microsomal fraction of embryonic chick brain.

3. [Biochemical differences of DNA-polymerases in leukemic cells].

4. A diploid rat liver cell culture. 2. Effect of aflatoxin B1 on ribonucleic acid synthesis.

Review 5. RNA-dependent DNA polymerase (reverse transcriptase).

6. The discovery of HTLV-1, the first pathogenic human retrovirus.

7. Viruses and lymphocytes in rheumatoid arthritis. I. Studies on cultured rheumatoid lymphocytes.

8. Purification, characterization, and comparison of the DNA polymerases from two primate RNA tumor viruses.

9. RNA-directed DNA polymerase and virus-induced leukemia in mice.

10. A historical reflection on the discovery of human retroviruses.