Literature DB >> 411532

The effect of banol and paraoxon on the NADPH-cytochrome c reductase activity and cytochrome P-450 content in rats.

N K Neskovic, S L Vitorovic.   

Abstract

We investigated the effect of banol and paraoxon on the activity of NADPH-cytochrome c reductase and cytochrome P-450 concentration in microsomes of rats treated in vivo with these compounds alone, or in the presence of phenobarbitone. The results showed that banol reduced the NADPH-cytochrome c reductase activity and the concentration of cytochrome P-450, while paraoxon reduced the activity of NADPH-cytochrome c reductase, but increased the cytochrome P-450 concentration. Phenobarbitone stimulated an increased NADPH-cytochrome c reductase activity and cytochrome P-450 concentration. When applied with banol and paraoxon, phenobarbitone lowered their inhibitory effect.

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Year:  1977        PMID： 411532     DOI： 10.1007/bf01683719

Source DB:  PubMed          Journal:  Bull Environ Contam Toxicol        ISSN： 0007-4861            Impact factor:   2.151


  8 in total

1.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Further studies on the submicrosomal distribution of drug-metabolizing components in liver. Localization in fractions of smooth microsomes.

Authors:  T E Gram; D H Schroeder; D C Davis; R L Reagan; A M Guarino
Journal:  Biochem Pharmacol       Date:  1971-10       Impact factor: 5.858

4.  Induction by phenobarbital of reduced nicotinamide-adenine dinucleotide phosphate (NADPH) cytochrome c reductase in regenerating rat liver.

Authors:  R I Glazer; A C Sartorelli
Journal:  Biochem Pharmacol       Date:  1971-12       Impact factor: 5.858

5.  Kinetic parameters of drug-metabolizing enzymes in Ca 2+ -sedimented microsomes from rat liver.

Authors:  D L Cinti; P Moldeus; J B Schenkman
Journal:  Biochem Pharmacol       Date:  1972-12-15       Impact factor: 5.858

6.  Effects on drug metabolism of carbaryl and 1-naphthol in the mouse.

Authors:  C R Cress; A Strother
Journal:  Life Sci       Date:  1974-03-01       Impact factor: 5.037

7.  Microsomal electron transport. I. Reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase and cytochrome P-450 as electron carriers in microsomal NADPH-peroxidase activity.

Authors:  E G Hrycay; P J O'Brien
Journal:  Arch Biochem Biophys       Date:  1973-07       Impact factor: 4.013

8.  Inductive effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane(DDT), phenobarbital, and benzpyrene on microsomal cytochrome B450, ethyl isocyanide spectra, and metabolism in vivo of zoxazolamine and hexobarbital in the mouse.

Authors:  C O Abernathy; R M Philpot; F E Guthrie; E Hodgson
Journal:  Biochem Pharmacol       Date:  1971-09       Impact factor: 5.858
  8 in total
  1 in total

1.  Cytochrome P-450 content and NADPH-cytochrome c reductase activity in rats treated with carbaryl and propoxur.

Authors:  N Nesković; M Milosević; R Kljajić
Journal:  Bull Environ Contam Toxicol       Date:  1979-11       Impact factor: 2.151
  1 in total

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