Literature DB >> 411347

Chromosomal damage by alcohol in vitro and in vivo.

G Obe, H J Ristow, J Herha.   

Abstract

Alcohol has no damaging effects on human chromosomes in vitro. The chromosomes of alcoholics, however, show a significant elevation of aberrations. Alcohol inhibits cellular and cell free RNA synthesis. One possible reason for the mutagenic activity of alcohol in vivo may be an inhibition of cellular repair.

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Year:  1977        PMID: 411347     DOI: 10.1007/978-1-4899-5181-6_4

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN: 0065-2598            Impact factor:   2.622


  2 in total

1.  An hypothesis regarding the origin of aneuploidy in man: indirect evidence from an experimental model.

Authors:  M H Kaufman
Journal:  J Med Genet       Date:  1985-06       Impact factor: 6.318

2.  Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes.

Authors:  K Morimoto; T Takeshita
Journal:  Environ Health Perspect       Date:  1996-05       Impact factor: 9.031

  2 in total

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