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Literature DB >> 4113392

Histamine release from human leukocytes: modulation by a cytochalasin B-sensitive barrier.

Abstract

Cytochalasin B, a metabolic product of several fungi, enhances up to 10-fold the sensitivity and reactivity of human leukocytes to antigen E or anti-IgE-mediated histamine release. The effect of cytochalasin B is a result of its action on the second, antigen-independent, stage of histamine release. These data suggest that normally, antigen-triggered histamine release is modulated by a cytochalasin-sensitive barrier (CSB). This CSB modulation of histamine release can be separated from the modulating effect of cyclic adenosine monophosphate (AMP).

Entities: Chemical Species

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Year: 1972 PMID： 4113392 PMCID： PMC292344 DOI： 10.1172/JCI106998

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

14 in total

1. Pancreatic beta-cell web: its possible role in insulin secretion.

Authors: L Orci; K H Gabbay; W J Malaisse
Journal: Science Date: 1972-03-10 Impact factor: 47.728

2. Immunochemical and biologic properties of rat IgE. 3. Modulation of the IgE-mediated release of slow-reacting substance of anaphylaxis by agents influencing the level of cyclic 3',5'-adenosine monoposphate.

Authors: W J Kooman; R P Orange; K F Austen
Journal: J Immunol Date: 1970-11 Impact factor: 5.422

3. The immediate allergic response: in vitro action of cyclic AMP-active and other drugs on the two stages of histamine release.

Authors: L M Lichtenstein; R DeBernardo
Journal: J Immunol Date: 1971-10 Impact factor: 5.422

Histamine release from human leukocytes: modulation by a cytochalasin B-sensitive barrier.

1. Pancreatic beta-cell web: its possible role in insulin secretion.

2. Immunochemical and biologic properties of rat IgE. 3. Modulation of the IgE-mediated release of slow-reacting substance of anaphylaxis by agents influencing the level of cyclic 3',5'-adenosine monoposphate.

3. The immediate allergic response: in vitro action of cyclic AMP-active and other drugs on the two stages of histamine release.

4. The immediate allergic response: in vitro separation of antigen activation, decay and histamine release.

5. Cytochalasin B: effects on microfilaments and movement of melanin granules within melanocytes.

6. Cytochalasin B and release of growth hormone.

7. Microfilaments in cellular and developmental processes.

8. Effects of cytochalasins on mammalian cells.

9. Mast cells from human respiratory tissue and their in vitro reactivity.

10. Immunologic and cellular changes accompanying the therapy of pollen allergy.

1. Effects of cytochalasin B on pancreatic acinar cell structure and secretion.

2. Selective release of lysosomal hydrolases from phagocytic cells by cytochalasin B.

3. Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon.