Literature DB >> 4109853

Inhibition of the renin-angiotensinogen reaction by pepstatin.

F Gross, J Lazar, H Orth.   

Abstract

Pepstatin, an N-acylated pentapeptide obtained from culture filtrates of actinomycetes and first characterized as an inhibitor of pepsin, produces inhibition of the renin-substrate reaction both in vitro and in vivo.

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Year:  1972        PMID： 4109853     DOI： 10.1126/science.175.4022.656

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  Inhibition of the local hemorrhagic Shwartzman reaction by an acid proteinase.

Authors:  T Y Lin; H R Williams
Journal:  Experientia       Date:  1975-02-15

2.  Acid proteinase of hypothalamus. Purification, some properties, and action on somatostatin and substance P.

Authors:  T N Akopyan; A A Arutunyan; A Lajtha; A A Galoyan
Journal:  Neurochem Res       Date:  1978-02       Impact factor: 3.996

3.  [Kidney and hypertension].

Authors:  F Gross
Journal:  Klin Wochenschr       Date:  1972-07-01

4.  Effects of the renin inhibitor pepstatin on the blood pressure of intact and nephrectomized rats.

Authors:  J Lazar; H Orth; J Möhring; F Gross
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

5.  Can we develop new drugs for hypertension?

Authors:  F Gross
Journal:  Br J Clin Pharmacol       Date:  1982-01       Impact factor: 4.335

6.  Amino acid sequence of mouse submaxillary gland renin.

Authors:  K S Misono; J J Chang; T Inagami
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

Review 7.  Renin inhibitors as possible antihypertensive agents.

Authors:  K G Hofbauer; J M Wood
Journal:  Klin Wochenschr       Date:  1988-09-15

8.  Inhibition of cathepsin D-type proteinase of macrophages by pepstatin, a specific pepsin inhibitor, and other substances.

Authors:  M H McAdoo; A M Dannenberg; C J Hayes; S P James; J H Sanner
Journal:  Infect Immun       Date:  1973-04       Impact factor: 3.441

Review 9.  Clinical pharmacokinetics and efficacy of renin inhibitors.

Authors:  G A Rongen; J W Lenders; P Smits; T Thien
Journal:  Clin Pharmacokinet       Date:  1995-07       Impact factor: 6.447

10.  Purification and characterization of recombinant human renin for X-ray crystallization studies.

Authors:  Zhongren Wu; Maria G Cappiello; Boyd B Scott; Yuri Bukhtiyarov; Gerard M McGeehan
Journal:  BMC Biochem       Date:  2008-06-26       Impact factor: 4.059
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