Literature DB >> 4108647

Bleomycin, and antitumor antibiotic: improved microbiological assay and tissue distribution studies in normal mice.

R F Pittillo, C Woolley, L S Rice.   

Abstract

A microbiological assay was developed for bleomycin, an antitumor antibiotic reported to be active in human trials. The assay bacterium was a strain of Escherichia coli which is resistant to ethionine. Studies revealed relatively high concentrations of bleomycin in the blood and urine of mice after a single dose, < 0.33 ld(10), injected intraperitoneally.

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Year:  1971        PMID： 4108647      PMCID： PMC376363          DOI： 10.1128/am.22.4.564-566.1971

Source DB:  PubMed          Journal:  Appl Microbiol        ISSN： 0003-6919


  7 in total

1.  Determination of certain antitumor agents in mouse blood by microbiologic assay.

Authors:  D E Hunt; R F Pittillo
Journal:  Cancer Res       Date:  1968-06       Impact factor: 12.701

2.  Effects of bleomycin on transplantable mouse tumors.

Authors:  M Takeuchi; T Yamamoto
Journal:  J Antibiot (Tokyo)       Date:  1968-11       Impact factor: 2.649

3.  Biological studies on individual bleomycins.

Authors:  H Umezawa; M Ishizaka; K Kimura; J Iwanaga; T Takeuchi
Journal:  J Antibiot (Tokyo)       Date:  1968-10       Impact factor: 2.649

4.  Purification of bleomycins.

Authors:  H Umezawa; Y Suhara; T Takita; K Maeda
Journal:  J Antibiot (Tokyo)       Date:  1966-09       Impact factor: 2.649

5.  New antibiotics, bleomycin A and B.

Authors:  H Umezawa; K Maeda; T Takeuchi; Y Okami
Journal:  J Antibiot (Tokyo)       Date:  1966-09       Impact factor: 2.649

6.  Activity and toxicity of bleomycin.

Authors:  M Ishizuka; H Takayama; T Takeuchi; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1967-01       Impact factor: 2.649

7.  Biological studies on bleomycin A.

Authors:  T Ichikawa; A Matsuda; K Miyamoto; M Tsubosaki; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1967-07       Impact factor: 2.649
  7 in total
  3 in total

1.  A potential application for the intracerebral injection of drugs entrapped within liposomes in the treatment of human cerebral gliomas.

Authors:  R O McKeran; G Firth; S Oliver; D Uttley; S O'Laoire
Journal:  J Neurol Neurosurg Psychiatry       Date:  1985-12       Impact factor: 10.154

2.  Bleomycin clinical pharmacology by radioimmunoassay.

Authors:  S W Hall; J E Strong; A Broughton; M L Frazier; R S Benjamin
Journal:  Cancer Chemother Pharmacol       Date:  1982       Impact factor: 3.333

3.  Studies on the intracerebral injection of bleomycin free and entrapped within liposomes in the rat.

Authors:  G Firth; A S Oliver; R O McKeran
Journal:  J Neurol Neurosurg Psychiatry       Date:  1984-06       Impact factor: 10.154
  3 in total

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