Literature DB >> 4106488

Intrahepatic expression of serum hepatitis virus-associated antigens.

T S Edgington, D J Ritt.   

Abstract

SH virus-associated antigens have been identified in the liver and blood by immunofluorescence. This antigenic expression of the hepatitis agent or its genome is found in the cytoplasm of hepatocytes and other cells of the liver. Acute hepatitis is associated with hepatocellular localization of SH antigen, whereas alternative or additional SH antigen in the cytoplasm of nonhepatocytes is observed in chronic or recurrent hepatitis. Persistent intrahepatic SH antigen has also been observed in conversion from acute to chronic hepatitis, and the persistence of this virus-associated antigen in the liver may serve a significant pathogenetic role in mediating direct anti-tissue responses as well as local immune complex reactions. Competitive inhibition studies of SH antigen suggest at least two antigenically and sterically independent determinants on the SH particle.

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Year:  1971        PMID: 4106488      PMCID: PMC2139001          DOI: 10.1084/jem.134.4.871

Source DB:  PubMed          Journal:  J Exp Med        ISSN: 0022-1007            Impact factor:   14.307


  31 in total

1.  Additional specificities of Australia antigen and the possible identification of hepatitis carriers.

Authors:  C Levene; B S Blumberg
Journal:  Nature       Date:  1969-01-11       Impact factor: 49.962

2.  Particles associated with Australia antigen in the sera of patients with leukaemia, Down's Syndrome and hepatitis.

Authors:  M E Bayer; B S Blumberg; B Werner
Journal:  Nature       Date:  1968-06-15       Impact factor: 49.962

3.  Australia antigen and hepatitis.

Authors:  B S Blumberg; A I Sutnick; W T London
Journal:  JAMA       Date:  1969-03-10       Impact factor: 56.272

4.  Autologous immune-complex pathogenesis of experimental allergic glomerulonephritis.

Authors:  T S Edgington; R J Glassock; F J Dixon
Journal:  Science       Date:  1967-03-17       Impact factor: 47.728

5.  A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis.

Authors:  B S Blumberg; B J Gerstley; D A Hungerford; W T London; A I Sutnick
Journal:  Ann Intern Med       Date:  1967-05       Impact factor: 25.391

6.  Relation of Australia and SH antigens.

Authors:  A M Prince
Journal:  Lancet       Date:  1968-08-24       Impact factor: 79.321

7.  Direct immunofluorescent tissue culture assay for lymphocytic choriomeningitis virus.

Authors:  M B Oldstone; F J Dixon
Journal:  J Immunol       Date:  1968-05       Impact factor: 5.422

8.  An antigen detected in the blood during the incubation period of serum hepatitis.

Authors:  A M Prince
Journal:  Proc Natl Acad Sci U S A       Date:  1968-07       Impact factor: 11.205

9.  Australia antigen and the quest for a hepatitis virus.

Authors:  A I Sutnick; W T London; B S Blumberg
Journal:  Am J Dig Dis       Date:  1969-03

10.  Production of antibody against "Australia antigen" in rabbits.

Authors:  L Melartin; B S Blumberg
Journal:  Nature       Date:  1966-06-25       Impact factor: 49.962

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  17 in total

1.  HBs-Ag, HBc-Ag and virus-like particles in liver tissue.

Authors:  S Furuta; A Nagata; K Kiyosawa; T Takahashi; Y Akahane
Journal:  Gastroenterol Jpn       Date:  1975

2.  Detection of hepatitis A antigen by immunofluorescence.

Authors:  L R Mathiesen; S M Feinstone; R H Purcell; J A Wagner
Journal:  Infect Immun       Date:  1977-11       Impact factor: 3.441

3.  HBsAg uptake by macrophages in vitro: an immunofluorescence study.

Authors:  G Pepe; A Cifarelli; F Paradisi; F De Ritis
Journal:  Experientia       Date:  1979-03-15

4.  The localization of the Australia antigen in the liver by immunofluorescence.

Authors:  T Akeyama; T Kamada; T Koizumi; H Abe
Journal:  J Clin Pathol       Date:  1972-12       Impact factor: 3.411

5.  Hepatitis-associated antigen in immunofluorescence. I. Interfering factors.

Authors:  M D Beccati; G Fabris; I Nenci
Journal:  Histochem J       Date:  1974-11

Review 6.  Clinical pathologic correlation in viral hepatitis. The effect of the virus on the liver.

Authors:  H Popper
Journal:  Am J Pathol       Date:  1975-12       Impact factor: 4.307

7.  Hepatitis B antigens in serum and liver of chimpanzees acutely infected with hepatitis B virus.

Authors:  K R Berquist; J M Peterson; B L Murphy; J W Ebert; J E Maynard; R H Purcell
Journal:  Infect Immun       Date:  1975-09       Impact factor: 3.441

8.  The pathology of viral hepatitis types A and B in chimpanzees. A comparison.

Authors:  J L Dienstag; H Popper; R H Purcell
Journal:  Am J Pathol       Date:  1976-10       Impact factor: 4.307

Review 9.  Recent advances in the identification of hepatitis viruses.

Authors:  J L Dienstag; R H Purcell
Journal:  Postgrad Med J       Date:  1977-07       Impact factor: 2.401

10.  DNA synthesized in the hepatitis B Dane particle DNA polymerase reaction.

Authors:  L I Lutwick; W S Robinson
Journal:  J Virol       Date:  1977-01       Impact factor: 5.103

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