Literature DB >> 410031

Histopathogenesis of 7,12-diemthylbenz(a)anthracene-induced rat mammary tumors.

S Z Haslam, H A Bern.   

Abstract

The histopathogenesis and growth behavior of mammary tumors and dysplasias induced by a single intragastric dose of 7,12-dimethylbenz[a]anthracene in 50-day-old virgin female Lewis rats were examined both in situ and after transplantation into gland-free mammary fat pads of syngeneic hosts. Terminal mammary ductules are indicated as a site of origin of both ovarian hormone-dependent mammary tumors and spontaneously gegressing mammary tumors, and terminal ductule hyperplasia appears to be an early stage in mammary tumor formation. The precancerous nature of hyperplastic alveolar nodules induced by dimethylbenzanthracene in rats has been further examined, and our studies indicate that these nodules are not significantly preneoplastic.

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Year:  1977        PMID： 410031      PMCID： PMC431827          DOI： 10.1073/pnas.74.9.4020

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

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Journal:  J Natl Cancer Inst       Date:  1964-06       Impact factor: 13.506

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Authors:  S YOUNG; D M COWAN; L E SUTHERLAND
Journal:  J Pathol Bacteriol       Date:  1963-04

3.  Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression.

Authors:  C HUGGINS; L C GRAND; F P BRILLANTES
Journal:  Nature       Date:  1961-01-21       Impact factor: 49.962

Review 4.  Hormone dependence in breast cancer.

Authors:  W L McGuire; G C Chamness; M E Costlow; R E Shepherd
Journal:  Metabolism       Date:  1974-01       Impact factor: 8.694

5.  Early phases in the development of breast cancer.

Authors:  H S Gallager; J E Martin
Journal:  Cancer       Date:  1969-12       Impact factor: 6.860

6.  On the origin and progression of ductal carcinoma in the human breast.

Authors:  S R Wellings; H M Jensen
Journal:  J Natl Cancer Inst       Date:  1973-05       Impact factor: 13.506

7.  Mammary tumorigenesis in chemical carcinogen-treated mice. IV. Induction of mammary ductal hyperplasias.

Authors:  D Medina; M R Warner
Journal:  J Natl Cancer Inst       Date:  1976-08       Impact factor: 13.506

8.  Mammary tumorigenesis in chemical carcinogen-treated mice. VI. Tumor-producing capabilities of mammary dysplasias in BALB/cCrgl mice.

Authors:  D Medina
Journal:  J Natl Cancer Inst       Date:  1976-11       Impact factor: 13.506

Review 9.  Steroid-binding proteins of the mammary gland and their clinical significance in breast cancer.

Authors:  J L Wittliff; R G Mehta; P A Boyd; J E Goral
Journal:  J Toxicol Environ Health Suppl       Date:  1976

10.  Rapid induction of mammary carcinoma in the rat and the influence of hormones on the tumors.

Authors:  C HUGGINS; G BRIZIARELLI; H SUTTON
Journal:  J Exp Med       Date:  1959-01-01       Impact factor: 14.307
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  27 in total

Review 1.  Hormone-induced protection against breast cancer.

Authors:  Lakshmi Sivaraman; Daniel Medina
Journal:  J Mammary Gland Biol Neoplasia       Date:  2002-01       Impact factor: 2.673

2.  Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure.

Authors:  Tessa J Murray; Maricel V Maffini; Angelo A Ucci; Carlos Sonnenschein; Ana M Soto
Journal:  Reprod Toxicol       Date:  2006-10-24       Impact factor: 3.143

3.  Differentiation of a rat mammary cell line in vitro.

Authors:  R Dulbecco; M Bologna; M Unger
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

4.  Cell types and morphogenesis in the mammary gland.

Authors:  R Dulbecco; M Henahan; B Armstrong
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

5.  Organ culture passage enhances the oncogenicity of carcinogen-induced hyperplastic mammary nodules.

Authors:  E M Rivera; S D Hill; M Taylor
Journal:  In Vitro       Date:  1981-02

6.  Pubertal bisphenol A exposure alters murine mammary stem cell function leading to early neoplasia in regenerated glands.

Authors:  Danhan Wang; Hui Gao; Abhik Bandyopadhyay; Anqi Wu; I-Tien Yeh; Yidong Chen; Yi Zou; Changjiang Huang; Christi A Walter; Qiaoxiang Dong; Lu-Zhe Sun
Journal:  Cancer Prev Res (Phila)       Date:  2014-02-11

Review 7.  Rat models of premalignant breast disease.

Authors:  H J Thompson; M Singh
Journal:  J Mammary Gland Biol Neoplasia       Date:  2000-10       Impact factor: 2.673

8.  In utero exposure to bisphenol A shifts the window of susceptibility for mammary carcinogenesis in the rat.

Authors:  Angela M Betancourt; Isam A Eltoum; Renee A Desmond; Jose Russo; Coral A Lamartiniere
Journal:  Environ Health Perspect       Date:  2010-11       Impact factor: 9.031

9.  Progesterone receptor A-regulated gene expression in mammary organoid cultures.

Authors:  Sarah J Santos; Mark D Aupperlee; Jianwei Xie; Srinivasan Durairaj; Richard Miksicek; Susan E Conrad; Jeffrey R Leipprandt; Ying S Tan; Richard C Schwartz; Sandra Z Haslam
Journal:  J Steroid Biochem Mol Biol       Date:  2009-04-19       Impact factor: 4.292

10.  Biological significance of interstitial collagenase in DMBA-induced mammary tumors of the rat.

Authors:  G Wirl
Journal:  Cancer Metastasis Rev       Date:  1984       Impact factor: 9.264
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