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Literature DB >> 409699

Localization of neurotensin-immunoreactive cells in the small intestine of man and various mammals.

V Helmstaedter, C Taugner, G E Feurle, W G Forssmann.

Abstract

Antibodies against synthetic bovine neurotensin were raised in rabbits and used to demonstrate neurotensin-immunreactive cells by immunohistochemical methods. In the jejunum and ileum of all species investigated (man, dog, monkey, cat, rabbit, sheep, rat, mouse, hamster, chinese hamster, gerbil, pig and guinea pig) cells were present in the mucosa, which reacted specifically with antineurotensin serum using the indirect immunofluorescence and peroxidase-antiperoxidase methods. In the monkey Tupaia the distribution of neurotensin-immunoreactive cells was examined by investigating serial sections through the entire gastro-entero-pancreatic (GEP) endocrine system, again showing most neurotensin-immunoreactive cells in the jejunum and ileum. The functional role of the presence of neurotensin immunoreactivity in the gut is discussed.

Entities: Disease Gene Species

Mesh：

Substances：
Neurotensin

Year: 1977 PMID： 409699 DOI： 10.1007/bf00511208

Source DB: PubMed Journal: Histochemistry ISSN： 0301-5564

14 in total

1. Hyperglycemia and hyperglucagonemia following neurotensin administration.

Authors: K Nagai; L A Frohman
Journal: Life Sci Date: 1976-07-15 Impact factor: 5.037

2. Induction of antibodies to porcine ACTH in rabbits with nonsteroidogenic polymers of BSA and ACTH.

Authors: M Reichlin; J J Schnure; V K Vance
Journal: Proc Soc Exp Biol Med Date: 1968-06

3. The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami.

Authors: R Carraway; S E Leeman
Journal: J Biol Chem Date: 1973-10-10 Impact factor: 5.157

4. Hyperglycemic effect of neurotensin, a hypothalamic peptide.

Authors: R E Carraway; L M Demers; S E Leeman
Journal: Endocrinology Date: 1976-12 Impact factor: 4.736

5. Effects of neurotensin and substance P on plasma insulin, glucagon and glucose levels.

Authors: M Brown; W Vale
Journal: Endocrinology Date: 1976-03 Impact factor: 4.736

6. Characterization of radioimmunoassayable neurotensin in the rat. Its differential distribution in the central nervous system, small intestine, and stomach.

Authors: R Carraway; S E Leeman
Journal: J Biol Chem Date: 1976-11-25 Impact factor: 5.157

7. Radioimmunoassay for neurotensin, a hypothalamic peptide.

Authors: R Carraway; S E Leeman
Journal: J Biol Chem Date: 1976-11-25 Impact factor: 5.157

8. Isolation of a tridecapeptide from bovine intestinal tissue and its partial characterization as neurotensin.

Authors: P Kitabgi; R Carraway; S E Leeman
Journal: J Biol Chem Date: 1976-11-25 Impact factor: 5.157

9. Cardiovascular and metabolic actions of neurotensin and (Gln4)-Neurotensin.

Authors: S Rosell; E Burcher; D Chang; K Folkers
Journal: Acta Physiol Scand Date: 1976-12

10. Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit.

Authors: A H COONS; E H LEDUC; J M CONNOLLY
Journal: J Exp Med Date: 1955-07-01 Impact factor: 14.307

35 in total

Localization of neurotensin-immunoreactive cells in the small intestine of man and various mammals.

1. Hyperglycemia and hyperglucagonemia following neurotensin administration.

2. Induction of antibodies to porcine ACTH in rabbits with nonsteroidogenic polymers of BSA and ACTH.

3. The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami.

4. Hyperglycemic effect of neurotensin, a hypothalamic peptide.

5. Effects of neurotensin and substance P on plasma insulin, glucagon and glucose levels.

6. Characterization of radioimmunoassayable neurotensin in the rat. Its differential distribution in the central nervous system, small intestine, and stomach.

7. Radioimmunoassay for neurotensin, a hypothalamic peptide.

8. Isolation of a tridecapeptide from bovine intestinal tissue and its partial characterization as neurotensin.

9. Cardiovascular and metabolic actions of neurotensin and (Gln4)-Neurotensin.

10. Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit.

1. Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process.

2. Species-specific effects of neurotensin on gallbladder contraction in vitro.

3. Ultrastructural identification of a new cell type--the N-cell as the source of neurotensin in the gut mucosa.

4. Immunohistochemical identification of gastrointestinal neurotensin cells in human embryos.

Review 5. Immunocytochemical method for the detection of terminal deoxynucleotidyl transferase in acute leukemia.

6. Evidence for the presence of xenopsin-related peptide(s) in the gastric mucosa of mammals.

7. Distinct immunohistochemical findings in columnar epithelium of esophageal inlet patch and of Barrett's esophagus.

8. Regulation of gastric acid secretion by neurotensin in man. Evidence against a hormonal role.

9. Epidermal growth factor and neurotensin induce microvillus hypertrophy following massive enterectomy.

10. Expression of neurotensin messenger RNA in a human carcinoid tumor.