Literature DB >> 4096539

Pig-skin epidermal calmodulin: effects of antagonists of calmodulin on DNA synthesis of pig-skin epidermis.

H Iizuka, Y Hashimoto, M Hirokawa, S Matsuo, T Mizumoto, A Ohkawara.   

Abstract

Although epidermal keratinocytes contain significant amounts of calmodulin, the exact role of calmodulin in epidermal biological activity remains to be determined. Pig-skin (epidermal) calmodulin was purified to homogeneity by DEAE/Sepharose- and phenothiazine-affinity-column chromatography. The characteristics of the purified calmodulin proved to be in good agreement with those of calmodulin obtained from other sources. Phenothiazines (trifluoperazine and chlorpromazine), mepacrine, propranolol, and colchicine inhibited the effect of the purified epidermal calmodulin on the calmodulin-deficient phosphodiesterase of bovine heart. These calmodulin antagonists all had inhibitory effects on the thymidine incorporation of pig-skin epidermal keratinocytes. These observations support the assumption that calmodulin might play an important role in epidermal keratinocyte proliferation.

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Year:  1985        PMID： 4096539     DOI： 10.1007/BF00409220

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  25 in total

1.  Calcium-dependent protein modulator of cyclic nucleotide phosphodiesterases from mouse epidermis.

Authors:  A W Murray; A Rogers
Journal:  Biochem J       Date:  1978-12-15       Impact factor: 3.857

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

Review 3.  Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells.

Authors:  A R Means; J S Tash; J G Chafouleas
Journal:  Physiol Rev       Date:  1982-01       Impact factor: 37.312

4.  Biologically active calmodulin levels are elevated in both involved and uninvolved epidermis in psoriasis.

Authors:  W F Tucker; S MacNeil; S S Bleehen; S Tomlinson
Journal:  J Invest Dermatol       Date:  1984-03       Impact factor: 8.551

5.  Calmodulin levels are grossly elevated in the psoriatic lesion.

Authors:  P C van de Kerkhof; P E van Erp
Journal:  Br J Dermatol       Date:  1983-02       Impact factor: 9.302

6.  Lack of tissue specificity of calmodulin: a rapid and high-yield purification method.

Authors:  S Kakiuchi; K Sobue; R Yamazaki; J Kambayashi; M Sakon; G Kosaki
Journal:  FEBS Lett       Date:  1981-04-20       Impact factor: 4.124

7.  Effects of adenosine and 2'-deoxyadenosine on epidermal keratinocyte proliferation: its relation to cyclic AMP formation.

Authors:  H Iizuka; R Adachi; H Koizumi; T Aoyagi; A Ohkawara; Y Miura
Journal:  J Invest Dermatol       Date:  1984-06       Impact factor: 8.551

8.  Quantitative determinations of calmodulin in the supernatant and particulate fractions of mammalian tissues.

Authors:  S Kakiuchi; S Yasuda; R Yamazaki; Y Teshima; K Kanda; R Kakiuchi; K Sobue
Journal:  J Biochem       Date:  1982-10       Impact factor: 3.387

9.  Inhibitors of epidermal cell DNA synthesis in surviving pig skin in vitro.

Authors:  J R Taylor; K M Halprin; V Levine
Journal:  J Invest Dermatol       Date:  1980-03       Impact factor: 8.551

10.  Calmodulin activities are significantly increased in both uninvolved and involved epidermis in psoriasis.

Authors:  T Mizumoto; Y Hashimoto; M Hirokawa; N Ohkuma; H Iizuka; A Ohkawara
Journal:  J Invest Dermatol       Date:  1985-11       Impact factor: 8.551
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  1 in total

1.  UVB-induced calmodulin increase in pig epidermis: analysis of the effect of the calmodulin antagonist, W-13.

Authors:  A Takagi; H Iizuka
Journal:  Arch Dermatol Res       Date:  1995       Impact factor: 3.017
  1 in total

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