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Literature DB >> 409640

The direct effect of hypoglycaemic sulphonylureas on myocardial contractile force and arterial blood pressure.

Abstract

The cardiovascular effects of glibenclamide, gliclazide and carbutamide were studied on myocardial contractile force, cardiac output, mean arterial pressure and heart rate in 43 intact, 14 pancreatectomized and 18 adrenalectomized dogs. It is shown that a positive inotropic and hypertensive effect of hypoglycaemic sulphonylureas develops without the mediation of glucagon, insulin or adrenaline. Contrary to the other investigated sulphonylureas, glibenclamide reduced myocardial contractile force and arterial blood pressure.

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Year: 1977 PMID： 409640 DOI： 10.1007/bf01234506

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

17 in total

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Authors: R F Bradley; H Dolger; P H Forsham; H Seltzer
Journal: JAMA Date: 1975-05-26 Impact factor: 56.272

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Journal: Clin Chim Acta Date: 1962-01 Impact factor: 3.786

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Journal: Ann Intern Med Date: 1971-10 Impact factor: 25.391

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Journal: Lancet Date: 1971-07-24 Impact factor: 79.321

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Authors: S E Crockett; D Marsh; R P Lewis; M Tzagournis
Journal: Metabolism Date: 1974-08 Impact factor: 8.694

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Authors: C L Meinert; G L Knatterud; T E Prout; C R Klimt
Journal: Diabetes Date: 1970 Impact factor: 9.461

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Authors: M Garcia; M Miller; A M Moses
Journal: Ann Intern Med Date: 1971-10 Impact factor: 25.391

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Authors: P R Maroko; J K Kjekshus; B E Sobel; T Watanabe; J W Covell; J Ross; E Braunwald
Journal: Circulation Date: 1971-01 Impact factor: 29.690

9. The effect of sulfonylurea drugs on rabbit myocardial contractility, canine purkinje fiber automaticity, and adenyl cyclase activity from rabbit and human hearts.

Authors: K C Lasseter; G S Levey; R F Palmer; J S McCarthy
Journal: J Clin Invest Date: 1972-09 Impact factor: 14.808

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Authors: T P Graham; J W Covell; E H Sonnenblick; J Ross; E Braunwald
Journal: J Clin Invest Date: 1968-02 Impact factor: 14.808

8 in total

Review 1. Drug-induced hypertension. Recognition and management in older patients.

Authors: P W de Leeuw
Journal: Drugs Aging Date: 1997-09 Impact factor: 3.923

2. Effect of diabetes therapy on the myocardium in experimental diabetes.

Authors: G Pogátsa; M Bihari-Varga; G Szinay
Journal: Acta Diabetol Lat Date: 1979 Apr-Jun

3. Effects of glyburide (glibenclamide) on myocardial function in Langendorff perfused rabbit heart and on myocardial contractility and slow calcium current in guinea-pig single myocytes.

Authors: Said Y Khatib; Mark R Boyett
Journal: Mol Cell Biochem Date: 2003-01 Impact factor: 3.396