Literature DB >> 4096304

Anti-inflammatory effect of intraventricularly administered histamine in rats.

S K Bhattacharya, N Das.   

Abstract

Intracerebroventricularly (icv) administered histamine (5, 10 and 20 micrograms) produced a dose-related anti-inflammatory effect against carrageenin-induced pedal edema in rats. The effect of histamine was mimicked by the H1 receptor agonist, 2-methylhistamine, but not by the H2 receptor agonist, 4-methylhistamine. The anti-inflammatory effect of centrally administered histamine was antagonised by mepyramine, a H1 receptor antagonist, but not by cimetidine, a H2 receptor antagonist. The anti-inflammatory effect of icv histamine was inhibited in bilaterally adrenalectomised rats but was unaffected by peripheral chemical sympathectomy induced by 6-hydroxydopamine.

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Year:  1985        PMID： 4096304     DOI： 10.1007/BF01966584

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  8 in total

1.  Acidic antiinflammatory agents--correlations of some physical, pharmacological and clinical data.

Authors:  J G Lombardino; I G Otterness; E H Wiseman
Journal:  Arzneimittelforschung       Date:  1975-10

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Authors:  C A WINTER; E A RISLEY; G W NUSS
Journal:  Proc Soc Exp Biol Med       Date:  1962-12

Review 3.  Role of brain monoamines and histamine in regulation of anterior pituitary secretion.

Authors:  R I Weiner; W F Ganong
Journal:  Physiol Rev       Date:  1978-10       Impact factor: 37.312

4.  The cardiovascular effects of intraventricularly administered histamine in the anaesthetised rat.

Authors:  L Finch; P E Hicks
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-05       Impact factor: 3.000

Review 5.  The pharmacology of 6-hydroxydopamine.

Authors:  H Thoenen; J P Tranzer
Journal:  Annu Rev Pharmacol       Date:  1973       Impact factor: 13.820

6.  The role of the nervous system in local inflammatory responses.

Authors:  H F Fearn; S Karady; G B West
Journal:  J Pharm Pharmacol       Date:  1965-12       Impact factor: 3.765

7.  Analgesic effect of histamine induced by intracerebral injection into mice.

Authors:  Y H Chung; H Miyake; C Kamei; K Tasaka
Journal:  Agents Actions       Date:  1984-10

8.  Schizophrenia as a prostaglandin deficiency disease.

Authors:  D F Horrobin
Journal:  Lancet       Date:  1977-04-30       Impact factor: 79.321
  8 in total
  2 in total

1.  Changes in corticosterone levels under different degrees of acute inflammation in mice.

Authors:  S L Chio; Y M Sin
Journal:  Agents Actions       Date:  1992-05

2.  A23187-induced pulmonary gas trapping and inflammation in the guinea pig.

Authors:  P W Stengel; G D Williams; S A Silbaugh
Journal:  Agents Actions       Date:  1991-03
  2 in total

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