Literature DB >> 4092194

Phase II trial of 4'-deoxydoxorubicin in patients with advanced breast cancer.

S P Leitner, E S Casper, T B Hakes, R J Kaufman, R J Winn, M Scoppetuolo, V Raymond, N L Geller, C W Young.   

Abstract

4'Deoxydoxorubicin (25 mg/m2 iv every 3 weeks) was evaluated in 20 patients with advanced breast cancer. The patients had good performance status and had not been heavily pretreated. Although all patients experienced leukopenia, no major therapeutic responses were observed. Nonhematologic toxicity was mild. Further evaluation of 4'-deoxydoxorubicin at this dose and schedule is not warranted in patients with advanced breast cancer.

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Year:  1985        PMID: 4092194

Source DB:  PubMed          Journal:  Cancer Treat Rep        ISSN: 0361-5960


  5 in total

Review 1.  Anthracycline analogs: the past, present, and future.

Authors:  R B Weiss; G Sarosy; K Clagett-Carr; M Russo; B Leyland-Jones
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

2.  Phase II study of deoxydoxorubicin in previously untreated metastatic breast cancer.

Authors:  S Martino; B A Samal; B Redman; L Flaherty; M Kraut; M Simon; M Valdivieso
Journal:  Breast Cancer Res Treat       Date:  1990-12       Impact factor: 4.872

3.  Clinical cardiotoxicity of esorubicin (4'-deoxydoxorubicin,DxDx): prospective studies with serial gated heart scans and reports of selected cases. A Cancer and Leukemia Group B report.

Authors:  Q S Ringenberg; K J Propert; H B Muss; R B Weiss; R L Schilsky; C Modeas; M C Perry; L Norton; M Green
Journal:  Invest New Drugs       Date:  1990-05       Impact factor: 3.850

4.  Phase II trial of esorubicin (4' deoxydoxorubicin) in cancers of the breast, colon, kidney, lung and melanoma.

Authors:  T A Braich; S E Salmon; A Robertone; D S Alberts; S E Jones; T P Miller; H S Garewal
Journal:  Invest New Drugs       Date:  1986       Impact factor: 3.850

Review 5.  Fatal esorubicin-induced cardiomyopathy: report of a case and review of the literature.

Authors:  L F Diehl; A Banks; W Carter; M A Klein; H B Muss; R B Weiss
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

  5 in total

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